eF-site ID 2fhh-G
PDB Code 2fhh
Chain G

click to enlarge
Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273
Classification HYDROLASE
Compound 20S proteasome, alpha and beta subunits
Source (AAK46453)
Sequence G:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY
TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI
NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI
VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG
DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD
GAVDVPESRIAELARAIIESRS
Description


Functional site

1) chain G
residue 301
type
sequence T
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

2) chain G
residue 321
type
sequence T
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

3) chain G
residue 322
type
sequence Q
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

4) chain G
residue 327
type
sequence S
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

5) chain G
residue 331
type
sequence V
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

6) chain G
residue 346
type
sequence A
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

7) chain G
residue 347
type
sequence G
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

8) chain G
residue 348
type
sequence T
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

9) chain G
residue 349
type
sequence A
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

10) chain G
residue 352
type
sequence A
description BINDING SITE FOR RESIDUE M1N G 273
source : AC4

11) chain G
residue 424
type
sequence D
description BINDING SITE FOR RESIDUE M1N X 273
source : BC3

12) chain G
residue 301
type ACT_SITE
sequence T
description Nucleophile => ECO:0000305|PubMed:20711362
source Swiss-Prot : SWS_FT_FI1

13) chain G
residue 301
type SITE
sequence T
description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986
source Swiss-Prot : SWS_FT_FI2


Display surface

Download
Links