eF-site ID 2fhh-E PDB Code 2fhh Chain E click to enlarge Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273 Classification HYDROLASE Compound 20S proteasome, alpha and beta subunits Source (AAK46453) Sequence E:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD GAVDVPESRIAELARAIIESRS Description Functional site 1) chain E residue 301 type sequence T description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 2) chain E residue 320 type sequence S description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 3) chain E residue 321 type sequence T description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 4) chain E residue 322 type sequence Q description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 5) chain E residue 327 type sequence S description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 6) chain E residue 346 type sequence A description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 7) chain E residue 347 type sequence G description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 8) chain E residue 348 type sequence T description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 9) chain E residue 349 type sequence A description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 10) chain E residue 352 type sequence A description BINDING SITE FOR RESIDUE M1N E 273 source : AC3 11) chain E residue 424 type sequence D description BINDING SITE FOR RESIDUE M1N L 273 source : AC6 12) chain E residue 301 type ACT_SITE sequence T description Nucleophile => ECO:0000305|PubMed:20711362 source Swiss-Prot : SWS_FT_FI1 13) chain E residue 301 type SITE sequence T description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986 source Swiss-Prot : SWS_FT_FI2

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