eF-site ID 2fhh-C PDB Code 2fhh Chain C click to enlarge Title Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273 Classification HYDROLASE Compound 20S proteasome, alpha and beta subunits Source (AAK46453) Sequence C:  TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDY TATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKI NRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRI VSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDG DSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD GAVDVPESRIAELARAIIESRS Description Functional site 1) chain C residue 301 type sequence T description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 2) chain C residue 320 type sequence S description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 3) chain C residue 321 type sequence T description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 4) chain C residue 322 type sequence Q description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 5) chain C residue 327 type sequence S description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 6) chain C residue 346 type sequence A description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 7) chain C residue 347 type sequence G description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 8) chain C residue 348 type sequence T description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 9) chain C residue 349 type sequence A description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 10) chain C residue 352 type sequence A description BINDING SITE FOR RESIDUE M1N C 273 source : AC2 11) chain C residue 424 type sequence D description BINDING SITE FOR RESIDUE M1N J 273 source : AC5 12) chain C residue 301 type ACT_SITE sequence T description Nucleophile => ECO:0000305|PubMed:20711362 source Swiss-Prot : SWS_FT_FI1 13) chain C residue 301 type SITE sequence T description Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986 source Swiss-Prot : SWS_FT_FI2

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