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eF-site ID
|
2fh7-A |
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PDB Code
|
2fh7 |
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Chain
|
A |
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click to enlarge
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Title
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Crystal structure of the phosphatase domains of human PTP SIGMA |
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Classification
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HYDROLASE |
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Compound
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Receptor-type tyrosine-protein phosphatase S |
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Source
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(PTPRS_HUMAN) |
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Sequence
|
A: |
MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQF
TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY
INANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSAT
IVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIEL
ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTP
FLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAML
ERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL
EAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKR
LAFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD
YINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNST
IVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN
MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGE
GFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLS
IVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
AALEYLGS
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Description
|
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Functional site
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|
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1)
|
chain |
A |
| residue |
1557 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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2)
|
chain |
A |
| residue |
1589 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
3)
|
chain |
A |
| residue |
1633 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
A |
| residue |
1587-1597 |
| type |
prosite |
| sequence |
VHCSAGVGRTG
|
| description |
TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG
|
| source |
prosite : PS00383
|
|
|
5)
|
chain |
A |
| residue |
1878-1888 |
| type |
prosite |
| sequence |
VHCSAGVGRTG
|
| description |
TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG
|
| source |
prosite : PS00383
|
|
|
6)
|
chain |
A |
| residue |
1589 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
Phosphocysteine intermediate => ECO:0000305|PubMed:23820885
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
1880 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
Phosphocysteine intermediate => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
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