|
eF-site ID
|
2fh7-A |
PDB Code
|
2fh7 |
Chain
|
A |
|
click to enlarge
|
|
Title
|
Crystal structure of the phosphatase domains of human PTP SIGMA |
Classification
|
HYDROLASE |
Compound
|
Receptor-type tyrosine-protein phosphatase S |
Source
|
(PTPRS_HUMAN) |
|
Sequence
|
A: |
MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQF
TWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY
INANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSAT
IVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIEL
ATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTP
FLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAML
ERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALL
EAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKR
LAFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD
YINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNST
IVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN
MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGE
GFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLS
IVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ
AALEYLGS
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
1587-1597 |
type |
prosite |
sequence |
VHCSAGVGRTG
|
description |
TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG
|
source |
prosite : PS00383
|
|
2)
|
chain |
A |
residue |
1878-1888 |
type |
prosite |
sequence |
VHCSAGVGRTG
|
description |
TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG
|
source |
prosite : PS00383
|
|
3)
|
chain |
A |
residue |
1589 |
type |
ACT_SITE |
sequence |
C
|
description |
Phosphocysteine intermediate => ECO:0000305|PubMed:23820885
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
A |
residue |
1880 |
type |
ACT_SITE |
sequence |
C
|
description |
Phosphocysteine intermediate => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
A |
residue |
1557 |
type |
BINDING |
sequence |
D
|
description |
BINDING => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
6)
|
chain |
A |
residue |
1589 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
7)
|
chain |
A |
residue |
1633 |
type |
BINDING |
sequence |
Q
|
description |
BINDING => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|