eF-site ID 2f9u-ABCD PDB Code 2f9u Chain A, B, C, D click to enlarge Title HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane Classification VIRAL PROTEIN Compound NS3 protease/helicase' Source Hepatitis C virus (AAT94284) Sequence A:  APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAT QTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQ DLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRG DSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCT RGVAKAVDFIPVENLETTMRSGS B:  KKGSVVIVGRIVLSGKPAIIPKK C:  QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASP KGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLV TRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPA GHAVGLFRAAVCTRGVAKAVDFIPVENLETTM D:  GSVVIVGRIVLSGKPAIIP Description Functional site 1) chain A residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN A 901 source : AC1 2) chain A residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN A 901 source : AC1 3) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN A 901 source : AC1 4) chain C residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN C 901 source : AC2 5) chain C residue 99 type sequence C description BINDING SITE FOR RESIDUE ZN C 901 source : AC2 6) chain C residue 145 type sequence C description BINDING SITE FOR RESIDUE ZN C 901 source : AC2 7) chain A residue 40 type sequence T description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 8) chain A residue 41 type sequence Q description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 9) chain A residue 42 type sequence T description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 10) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 11) chain A residue 132 type sequence I description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 12) chain A residue 136 type sequence K description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 13) chain A residue 137 type sequence G description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 14) chain A residue 138 type sequence S description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 15) chain A residue 139 type sequence S description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 16) chain A residue 155 type sequence R description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 17) chain A residue 156 type sequence A description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 18) chain A residue 157 type sequence A description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 19) chain A residue 159 type sequence C description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3 20) chain A residue 168 type sequence D description BINDING SITE FOR RESIDUE 5NH A 999 source : AC3

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