eF-site ID 2f91-AB PDB Code 2f91 Chain A, B click to enlarge Title 1.2A resolution structure of a crayfish trypsin complexed with a peptide inhibitor, SGTI Classification HYDROLASE/HYDROLASE INHIBITOR Compound hepatopancreas trypsin Source ORGANISM_COMMON: narrow-clawed crayfish; ORGANISM_SCIENTIFIC: Pontastacus leptodactylus; Sequence A:  IVGGTDATLGEFPYQLSFQETFIGFSFHFCGASIYNENYA ITAGHCVYGDDYENPSGLQIVAGELDMSVNEGSEQIITVS KIILHENFDYNLLDNDISLLKLSGSLTFNDNVAPIALPEQ GHTATGDVIVTGWGTTSEGGNTPDVLQKVTVPLVSDEDCR ADYGADEILDSMICAGVPEGGKDSCQGDSGGPLAASDTGS TYLAGIVSWGYGCARPGYPGVYTEVSYHVDWIKANAV B:  QECTPGQTKKQDCNTCNCTPTGVWACTRKGCPP Description Functional site 1) chain A residue 70 type sequence E description BINDING SITE FOR RESIDUE CD A 401 source : AC1 2) chain A residue 72 type sequence D description BINDING SITE FOR RESIDUE CD A 401 source : AC1 3) chain A residue 75 type sequence V description BINDING SITE FOR RESIDUE CD A 401 source : AC1 4) chain A residue 77 type sequence E description BINDING SITE FOR RESIDUE CD A 401 source : AC1 5) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE CD A 401 source : AC1 6) chain A residue 135 type sequence D description BINDING SITE FOR RESIDUE CD A 402 source : AC2 7) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE CD A 402 source : AC2 8) chain A residue 60 type sequence Y description BINDING SITE FOR RESIDUE CD A 403 source : AC3 9) chain A residue 21 type sequence D description BINDING SITE FOR RESIDUE CD A 404 source : AC4 10) chain A residue 60 type sequence Y description BINDING SITE FOR RESIDUE CD A 404 source : AC4 11) chain A residue 165 type sequence D description BINDING SITE FOR RESIDUE CD A 405 source : AC5 12) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE CD A 405 source : AC5 13) chain A residue 180 type sequence M description BINDING SITE FOR RESIDUE CD A 405 source : AC5 14) chain A residue 231 type sequence E description BINDING SITE FOR RESIDUE CD A 405 source : AC5 15) chain A residue 125 type sequence E description BINDING SITE FOR RESIDUE CD A 406 source : AC6 16) chain A residue 93 type sequence N description BINDING SITE FOR RESIDUE CL A 407 source : AC7 17) chain A residue 135 type sequence D description BINDING SITE FOR RESIDUE CL A 407 source : AC7 18) chain A residue 169 type sequence R description BINDING SITE FOR RESIDUE CL A 407 source : AC7 19) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE CL A 407 source : AC7 20) chain A residue 135 type sequence D description BINDING SITE FOR RESIDUE CL A 408 source : AC8 21) chain A residue 159 type sequence T description BINDING SITE FOR RESIDUE CL A 408 source : AC8 22) chain A residue 161 type sequence P description BINDING SITE FOR RESIDUE CL A 408 source : AC8 23) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE CL A 408 source : AC8 24) chain A residue 188 type sequence K description BINDING SITE FOR RESIDUE CL A 408 source : AC8 25) chain B residue 29 type SITE sequence R description Reactive bond source Swiss-Prot : SWS_FT_FI1 26) chain A residue 53-58 type prosite sequence ITAGHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ITAGHC source prosite : PS00134 27) chain A residue 189-200 type prosite sequence DSCQGDSGGPLA description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLA source prosite : PS00135 28) chain A residue 200-211 type prosite sequence AASDTGSTYLAG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. AASDTGSTYLAG source prosite : PS00141

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