eF-site ID 2f6j-ABCP PDB Code 2f6j Chain A, B, C, P click to enlarge Title Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4me3 bound state Classification TRANSCRIPTION Compound bromodomain PHD finger transcription factor Source (2F6J) Sequence A:  DTKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEA ELIDEYVCPQCQSTEDAXTVLTPLTEKDYEGLKRVLRSLQ AHKXAWPFLEPVDPNDAPDYYGVIKEPXDLATXEERVQRR YYEKLTEFVADXTKIFDNCRYYNPSDSPFYQCAEVLESFF VQKLKGFK B:  TKLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAE LIDEYVCPQCQSTEDAXTVLTPLTEKDYEGLKRVLRSLQA HKXAWPFLEPVDPNDAPDYYGVIKEPXDLATXEERVQRRY YEKLTEFVADXTKIFDNCRYYNPSDSPFYQCAEVLESFFV QKLKGFK C:  KLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAEL IDEYVCPQCQSTEDAXTVLTPLTEKDYEGLKRVLRSLQAH KXAWPFLEPVDPNDAPDYYGVIKEPXDLATXEERVQRRYY EKLTEFVADXTKIFDNCRYYNPSDSPFYQCAEVLESFFVQ KLKGFK P:  ARTXQT Description (1)  bromodomain PHD finger transcription factor/histone H3 tail (1-15)K4me3 Functional site 1) chain A residue 11 type sequence C description BINDING SITE FOR RESIDUE ZN A 1001 source : AC1 2) chain A residue 13 type sequence C description BINDING SITE FOR RESIDUE ZN A 1001 source : AC1 3) chain A residue 34 type sequence H description BINDING SITE FOR RESIDUE ZN A 1001 source : AC1 4) chain A residue 37 type sequence C description BINDING SITE FOR RESIDUE ZN A 1001 source : AC1 5) chain A residue 26 type sequence C description BINDING SITE FOR RESIDUE ZN A 1002 source : AC2 6) chain A residue 29 type sequence C description BINDING SITE FOR RESIDUE ZN A 1002 source : AC2 7) chain A residue 53 type sequence C description BINDING SITE FOR RESIDUE ZN A 1002 source : AC2 8) chain A residue 56 type sequence C description BINDING SITE FOR RESIDUE ZN A 1002 source : AC2 9) chain B residue 11 type sequence C description BINDING SITE FOR RESIDUE ZN B 1003 source : AC3 10) chain B residue 13 type sequence C description BINDING SITE FOR RESIDUE ZN B 1003 source : AC3 11) chain B residue 34 type sequence H description BINDING SITE FOR RESIDUE ZN B 1003 source : AC3 12) chain B residue 37 type sequence C description BINDING SITE FOR RESIDUE ZN B 1003 source : AC3 13) chain B residue 26 type sequence C description BINDING SITE FOR RESIDUE ZN B 1004 source : AC4 14) chain B residue 29 type sequence C description BINDING SITE FOR RESIDUE ZN B 1004 source : AC4 15) chain B residue 53 type sequence C description BINDING SITE FOR RESIDUE ZN B 1004 source : AC4 16) chain B residue 56 type sequence C description BINDING SITE FOR RESIDUE ZN B 1004 source : AC4 17) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE ZN C 1005 source : AC5 18) chain C residue 13 type sequence C description BINDING SITE FOR RESIDUE ZN C 1005 source : AC5 19) chain C residue 34 type sequence H description BINDING SITE FOR RESIDUE ZN C 1005 source : AC5 20) chain C residue 37 type sequence C description BINDING SITE FOR RESIDUE ZN C 1005 source : AC5 21) chain C residue 26 type sequence C description BINDING SITE FOR RESIDUE ZN C 1006 source : AC6 22) chain C residue 29 type sequence C description BINDING SITE FOR RESIDUE ZN C 1006 source : AC6 23) chain C residue 53 type sequence C description BINDING SITE FOR RESIDUE ZN C 1006 source : AC6 24) chain C residue 56 type sequence C description BINDING SITE FOR RESIDUE ZN C 1006 source : AC6 25) chain A residue 90-147 type prosite sequence AWPFLEPVDPNDAPDYYGVIKEPXDLATXEERVQRRYYEK LTEFVADXTKIFDNCRYY description BROMODOMAIN_1 Bromodomain signature. AwpFlepvDpndap..DYYgvIkepMdlatMeervqrry..Yekltefvadmtk.IfdNCryY source prosite : PS00633 26) chain A residue 11-26 type prosite sequence CICKTPYDESKFYIGC description EGF_2 EGF-like domain signature 2. CiCktPYdeskfyigC source prosite : PS01186 27) chain A residue 11-56 type prosite sequence CICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAELIDE YVCPQC description ZF_PHD_1 Zinc finger PHD-type signature. Ci.Cktpydeskfy...................................IgCdr..Cqnw.YHgrCvgilqseaelide................................YvCpqC source prosite : PS01359 28) chain A residue 10 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 29) chain C residue 17 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 30) chain C residue 23 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 31) chain C residue 32 type SITE sequence W description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 32) chain A residue 17 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 33) chain A residue 23 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 34) chain A residue 32 type SITE sequence W description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 35) chain B residue 10 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 36) chain B residue 17 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 37) chain B residue 23 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 38) chain B residue 32 type SITE sequence W description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 39) chain C residue 10 type SITE sequence Y description Histone H3K4me3 binding source Swiss-Prot : SWS_FT_FI2 40) chain A residue 8-59 type ZN_FING sequence KLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAEL IDEYVCPQCQST description PHD-type 2 => ECO:0000255|PROSITE-ProRule:PRU00146 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 8-59 type ZN_FING sequence KLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAEL IDEYVCPQCQST description PHD-type 2 => ECO:0000255|PROSITE-ProRule:PRU00146 source Swiss-Prot : SWS_FT_FI1 42) chain C residue 8-59 type ZN_FING sequence KLYCICKTPYDESKFYIGCDRCQNWYHGRCVGILQSEAEL IDEYVCPQCQST description PHD-type 2 => ECO:0000255|PROSITE-ProRule:PRU00146 source Swiss-Prot : SWS_FT_FI1

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