eF-site ID 2f16-N PDB Code 2f16 Chain N click to enlarge Title Crystal structure of the yeast 20S proteasome in complex with bortezomib Classification HYDROLASE Compound Proteasome component Y7 Source ORGANISM_COMMON: baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence N:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL Description Functional site 1) chain N residue 1 type sequence T description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 2) chain N residue 19 type sequence R description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 3) chain N residue 20 type sequence T description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 4) chain N residue 21 type sequence T description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 5) chain N residue 22 type sequence T description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 6) chain N residue 33 type sequence K description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 7) chain N residue 45 type sequence R description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 8) chain N residue 46 type sequence S description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 9) chain N residue 47 type sequence G description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 10) chain N residue 49 type sequence A description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 11) chain N residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000269|PubMed:9087403 source Swiss-Prot : SWS_FT_FI1

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