eF-site ID 2f16-H PDB Code 2f16 Chain H click to enlarge Title Crystal structure of the yeast 20S proteasome in complex with bortezomib Classification HYDROLASE Compound Proteasome component Y7 Source ORGANISM_COMMON: baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence H:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICD Description Functional site 1) chain H residue 1 type sequence T description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 2) chain H residue 20 type sequence S description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 3) chain H residue 21 type sequence T description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 4) chain H residue 22 type sequence Q description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 5) chain H residue 33 type sequence K description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 6) chain H residue 46 type sequence A description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 7) chain H residue 47 type sequence G description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 8) chain H residue 48 type sequence T description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 9) chain H residue 49 type sequence A description BINDING SITE FOR RESIDUE BO2 H 1400 source : AC1 10) chain H residue 114 type sequence H description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 11) chain H residue 118 type sequence S description BINDING SITE FOR RESIDUE BO2 N 1404 source : AC3 12) chain H residue 1 type catalytic sequence T description 177 source MCSA : MCSA1 13) chain H residue 17 type catalytic sequence D description 177 source MCSA : MCSA1 14) chain H residue 19 type catalytic sequence R description 177 source MCSA : MCSA1 15) chain H residue 33 type catalytic sequence K description 177 source MCSA : MCSA1 16) chain H residue 47 type catalytic sequence G description 177 source MCSA : MCSA1 17) chain H residue 129 type catalytic sequence S description 177 source MCSA : MCSA1 18) chain H residue 166 type catalytic sequence D description 177 source MCSA : MCSA1 19) chain H residue 169 type catalytic sequence S description 177 source MCSA : MCSA1 20) chain H residue 4-51 type prosite sequence VGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWC AGAGTAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD source prosite : PS00854

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