eF-site ID 2esl-F PDB Code 2esl Chain F click to enlarge Title Human Cyclophilin C in Complex with Cyclosporin A Classification ISOMERASE/IMMUNOSUPPRESSANT Compound Peptidyl-prolyl cis-trans isomerase C Source Homo sapiens (Human) (NOR00033) Sequence F:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW Description (1)  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C (E.C.5.2.1.8), CYCLOSPORIN A Functional site 1) chain F residue 93 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : AC2 2) chain F residue 68 type sequence E description BINDING SITE FOR RESIDUE CA F 3 source : AC3 3) chain F residue 77 type sequence E description BINDING SITE FOR RESIDUE CA F 3 source : AC3 4) chain F residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN D 5 source : AC5 5) chain F residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 E 10 source : BC1 6) chain F residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 E 10 source : BC1 7) chain F residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 8) chain F residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 9) chain F residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 10) chain F residue 155 type sequence W description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 11) chain F residue 89 type sequence R description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 12) chain F residue 94 type sequence F description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 13) chain F residue 97 type sequence Q description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 14) chain F residue 106 type sequence G description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 15) chain F residue 107 type sequence T description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 16) chain F residue 135 type sequence A description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 17) chain F residue 136 type sequence N description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 18) chain F residue 145 type sequence Q description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 19) chain F residue 147 type sequence F description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 20) chain F residue 155 type sequence W description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 21) chain F residue 160 type sequence H description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8

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