eF-site ID 2esl-D PDB Code 2esl Chain D click to enlarge Title Human Cyclophilin C in Complex with Cyclosporin A Classification ISOMERASE/IMMUNOSUPPRESSANT Compound Peptidyl-prolyl cis-trans isomerase C Source Homo sapiens (Human) (NOR00033) Sequence D:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW Description (1)  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C (E.C.5.2.1.8), CYCLOSPORIN A Functional site 1) chain D residue 93 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : AC2 2) chain D residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN D 5 source : AC5 3) chain D residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 D 9 source : AC9 4) chain D residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 D 9 source : AC9 5) chain D residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 D 9 source : AC9 6) chain D residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 7) chain D residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 8) chain D residue 155 type sequence W description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 9) chain D residue 89 type sequence R description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 10) chain D residue 94 type sequence F description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 11) chain D residue 97 type sequence Q description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 12) chain D residue 106 type sequence G description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 13) chain D residue 135 type sequence A description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 14) chain D residue 136 type sequence N description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 15) chain D residue 145 type sequence Q description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 16) chain D residue 147 type sequence F description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 17) chain D residue 155 type sequence W description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 18) chain D residue 160 type sequence H description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6

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