eF-site ID 2esl-ABCDEF PDB Code 2esl Chain A, B, C, D, E, F click to enlarge Title Human Cyclophilin C in Complex with Cyclosporin A Classification ISOMERASE/IMMUNOSUPPRESSANT Compound Peptidyl-prolyl cis-trans isomerase C Source Homo sapiens (Human) (NOR00033) Sequence A:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW B:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW C:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW D:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW E:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW F:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW Description (1)  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C (E.C.5.2.1.8), CYCLOSPORIN A Functional site 1) chain A residue 93 type sequence D description BINDING SITE FOR RESIDUE CA A 1 source : AC1 2) chain B residue 93 type sequence D description BINDING SITE FOR RESIDUE CA A 1 source : AC1 3) chain C residue 93 type sequence D description BINDING SITE FOR RESIDUE CA A 1 source : AC1 4) chain D residue 93 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : AC2 5) chain E residue 93 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : AC2 6) chain F residue 93 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : AC2 7) chain E residue 115 type sequence E description BINDING SITE FOR RESIDUE CA F 3 source : AC3 8) chain F residue 68 type sequence E description BINDING SITE FOR RESIDUE CA F 3 source : AC3 9) chain F residue 77 type sequence E description BINDING SITE FOR RESIDUE CA F 3 source : AC3 10) chain A residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN A 4 source : AC4 11) chain B residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN A 4 source : AC4 12) chain C residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN A 4 source : AC4 13) chain D residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN D 5 source : AC5 14) chain E residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN D 5 source : AC5 15) chain F residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN D 5 source : AC5 16) chain A residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 17) chain A residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 18) chain A residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 19) chain B residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 20) chain B residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 21) chain B residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 B 7 source : AC7 22) chain B residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 B 7 source : AC7 23) chain B residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 B 7 source : AC7 24) chain C residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 7 source : AC7 25) chain C residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 B 7 source : AC7 26) chain A residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 8 source : AC8 27) chain A residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 C 8 source : AC8 28) chain C residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 C 8 source : AC8 29) chain C residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 C 8 source : AC8 30) chain C residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 C 8 source : AC8 31) chain D residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 D 9 source : AC9 32) chain D residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 D 9 source : AC9 33) chain D residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 D 9 source : AC9 34) chain E residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 D 9 source : AC9 35) chain E residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 D 9 source : AC9 36) chain E residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 E 10 source : BC1 37) chain E residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 E 10 source : BC1 38) chain E residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 E 10 source : BC1 39) chain F residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 E 10 source : BC1 40) chain F residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 E 10 source : BC1 41) chain D residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 42) chain D residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 43) chain F residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 44) chain F residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 45) chain F residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 F 11 source : BC2 46) chain A residue 89 type sequence R description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 47) chain A residue 94 type sequence F description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 48) chain A residue 97 type sequence Q description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 49) chain A residue 106 type sequence G description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 50) chain A residue 107 type sequence T description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 51) chain A residue 135 type sequence A description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 52) chain A residue 136 type sequence N description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 53) chain A residue 137 type sequence A description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 54) chain A residue 145 type sequence Q description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 55) chain A residue 147 type sequence F description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 56) chain A residue 155 type sequence W description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 57) chain A residue 160 type sequence H description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 58) chain E residue 139 type sequence P description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 59) chain E residue 155 type sequence W description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 60) chain B residue 89 type sequence R description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 61) chain B residue 94 type sequence F description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 62) chain B residue 97 type sequence Q description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 63) chain B residue 106 type sequence G description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 64) chain B residue 135 type sequence A description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 65) chain B residue 136 type sequence N description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 66) chain B residue 137 type sequence A description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 67) chain B residue 145 type sequence Q description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 68) chain B residue 147 type sequence F description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 69) chain B residue 155 type sequence W description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 70) chain B residue 160 type sequence H description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 71) chain D residue 155 type sequence W description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 72) chain C residue 89 type sequence R description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 73) chain C residue 94 type sequence F description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 74) chain C residue 97 type sequence Q description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 75) chain C residue 106 type sequence G description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 76) chain C residue 135 type sequence A description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 77) chain C residue 136 type sequence N description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 78) chain C residue 137 type sequence A description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 79) chain C residue 145 type sequence Q description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 80) chain C residue 147 type sequence F description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 81) chain C residue 155 type sequence W description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 82) chain C residue 160 type sequence H description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 83) chain F residue 155 type sequence W description BINDING SITE FOR CHAIN K OF CYCLOSPORIN A source : BC5 84) chain B residue 155 type sequence W description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 85) chain D residue 89 type sequence R description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 86) chain D residue 94 type sequence F description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 87) chain D residue 97 type sequence Q description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 88) chain D residue 106 type sequence G description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 89) chain D residue 135 type sequence A description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 90) chain D residue 136 type sequence N description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 91) chain D residue 145 type sequence Q description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 92) chain D residue 147 type sequence F description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 93) chain D residue 155 type sequence W description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 94) chain D residue 160 type sequence H description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6 95) chain A residue 139 type sequence P description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 96) chain A residue 155 type sequence W description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 97) chain A residue 159 type sequence K description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 98) chain E residue 89 type sequence R description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 99) chain E residue 94 type sequence F description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 100) chain E residue 97 type sequence Q description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 101) chain E residue 106 type sequence G description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 102) chain E residue 135 type sequence A description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 103) chain E residue 136 type sequence N description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 104) chain E residue 145 type sequence Q description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 105) chain E residue 147 type sequence F description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 106) chain E residue 155 type sequence W description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 107) chain E residue 160 type sequence H description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 108) chain C residue 137 type sequence A description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 109) chain C residue 155 type sequence W description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 110) chain F residue 89 type sequence R description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 111) chain F residue 94 type sequence F description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 112) chain F residue 97 type sequence Q description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 113) chain F residue 106 type sequence G description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 114) chain F residue 107 type sequence T description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 115) chain F residue 135 type sequence A description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 116) chain F residue 136 type sequence N description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 117) chain F residue 145 type sequence Q description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 118) chain F residue 147 type sequence F description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 119) chain F residue 155 type sequence W description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 120) chain F residue 160 type sequence H description BINDING SITE FOR CHAIN N OF CYCLOSPORIN A source : BC8 121) chain A residue 82-99 type prosite sequence YKGSKFHRVIKDFMIQGG description CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgSkFHRVIkdFMiQGG source prosite : PS00170

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