eF-site ID 2esl-B PDB Code 2esl Chain B click to enlarge Title Human Cyclophilin C in Complex with Cyclosporin A Classification ISOMERASE/IMMUNOSUPPRESSANT Compound Peptidyl-prolyl cis-trans isomerase C Source Homo sapiens (Human) (NOR00033) Sequence B:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW Description (1)  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C (E.C.5.2.1.8), CYCLOSPORIN A Functional site 1) chain B residue 93 type sequence D description BINDING SITE FOR RESIDUE CA A 1 source : AC1 2) chain B residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN A 4 source : AC4 3) chain B residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 4) chain B residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 5) chain B residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 B 7 source : AC7 6) chain B residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 B 7 source : AC7 7) chain B residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 B 7 source : AC7 8) chain B residue 89 type sequence R description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 9) chain B residue 94 type sequence F description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 10) chain B residue 97 type sequence Q description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 11) chain B residue 106 type sequence G description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 12) chain B residue 135 type sequence A description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 13) chain B residue 136 type sequence N description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 14) chain B residue 137 type sequence A description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 15) chain B residue 145 type sequence Q description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 16) chain B residue 147 type sequence F description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 17) chain B residue 155 type sequence W description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 18) chain B residue 160 type sequence H description BINDING SITE FOR CHAIN J OF CYCLOSPORIN A source : BC4 19) chain B residue 155 type sequence W description BINDING SITE FOR CHAIN L OF CYCLOSPORIN A source : BC6

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