eF-site ID 2esl-A PDB Code 2esl Chain A click to enlarge Title Human Cyclophilin C in Complex with Cyclosporin A Classification ISOMERASE/IMMUNOSUPPRESSANT Compound Peptidyl-prolyl cis-trans isomerase C Source Homo sapiens (Human) (NOR00033) Sequence A:  RGPSVTAKVFFDVRIGDKDVGRIVIGLFGKVVPKTVENFV ALATGEKGYGYKGSKFHRVIKDFMIQGGDITTGDGTGGVS IYGETFPDENFKLKHYGIGWVSMANAGPDTNGSQFFITLT KPTWLDGKHVVFGKVIDGMTVVHSIELQATDGHDRPLTNC SIINSGKIDVKTPFVVEIADW Description (1)  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C (E.C.5.2.1.8), CYCLOSPORIN A Functional site 1) chain A residue 93 type sequence D description BINDING SITE FOR RESIDUE CA A 1 source : AC1 2) chain A residue 174 type sequence H description BINDING SITE FOR RESIDUE ZN A 4 source : AC4 3) chain A residue 168 type sequence D description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 4) chain A residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 5) chain A residue 170 type sequence M description BINDING SITE FOR RESIDUE SO4 A 6 source : AC6 6) chain A residue 179 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 8 source : AC8 7) chain A residue 180 type sequence A description BINDING SITE FOR RESIDUE SO4 C 8 source : AC8 8) chain A residue 89 type sequence R description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 9) chain A residue 94 type sequence F description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 10) chain A residue 97 type sequence Q description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 11) chain A residue 106 type sequence G description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 12) chain A residue 107 type sequence T description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 13) chain A residue 135 type sequence A description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 14) chain A residue 136 type sequence N description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 15) chain A residue 137 type sequence A description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 16) chain A residue 145 type sequence Q description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 17) chain A residue 147 type sequence F description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 18) chain A residue 155 type sequence W description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 19) chain A residue 160 type sequence H description BINDING SITE FOR CHAIN I OF CYCLOSPORIN A source : BC3 20) chain A residue 139 type sequence P description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 21) chain A residue 155 type sequence W description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 22) chain A residue 159 type sequence K description BINDING SITE FOR CHAIN M OF CYCLOSPORIN A source : BC7 23) chain A residue 82-99 type prosite sequence YKGSKFHRVIKDFMIQGG description CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgSkFHRVIkdFMiQGG source prosite : PS00170

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