eF-site ID 2ea2-A PDB Code 2ea2 Chain A click to enlarge Title h-MetAP2 complexed with A773812 Classification HYDROLASE Compound Methionine aminopeptidase 2 Source null (AMPM2_HUMAN) Sequence A:  KVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWR TTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKP GMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCA AHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTF NPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVME SYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIIKG GEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDV GHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYL MALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCK EVVSRGDDY Description Functional site 1) chain A residue 251 type sequence D description BINDING SITE FOR RESIDUE MN A 480 source : AC1 2) chain A residue 262 type sequence D description BINDING SITE FOR RESIDUE MN A 480 source : AC1 3) chain A residue 459 type sequence E description BINDING SITE FOR RESIDUE MN A 480 source : AC1 4) chain A residue 262 type sequence D description BINDING SITE FOR RESIDUE MN A 481 source : AC2 5) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE MN A 481 source : AC2 6) chain A residue 364 type sequence E description BINDING SITE FOR RESIDUE MN A 481 source : AC2 7) chain A residue 459 type sequence E description BINDING SITE FOR RESIDUE MN A 481 source : AC2 8) chain A residue 230 type sequence A description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 9) chain A residue 231 type sequence H description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 10) chain A residue 262 type sequence D description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 11) chain A residue 328 type sequence L description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 12) chain A residue 329 type sequence N description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 13) chain A residue 331 type sequence H description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 14) chain A residue 338 type sequence I description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 15) chain A residue 339 type sequence H description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 16) chain A residue 364 type sequence E description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 17) chain A residue 366 type sequence F description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 18) chain A residue 414 type sequence A description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 19) chain A residue 444 type sequence Y description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 20) chain A residue 447 type sequence L description BINDING SITE FOR RESIDUE F77 A 482 source : AC3 21) chain A residue 339 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:16540317 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 231 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:16540317 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 364 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 459 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 251 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 262 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 331 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 246-262 type prosite sequence DICKIDFGTHISGRIID description MAP_2 Methionine aminopeptidase subfamily 2 signature. DIcKIDfGtHISGriiD source prosite : PS01202

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