eF-site ID 2e9n-A PDB Code 2e9n Chain A click to enlarge Title Structure of h-CHK1 complexed with A767085 Classification TRANSFERASE Compound Serine/threonine-protein kinase Chk1 Source null (CHK1_HUMAN) Sequence A:  AVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVD MKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQY LFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRE RLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAM LAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL LHKILVENPSARITIPDIKKDRWYNKPLK Description Functional site 1) chain A residue 36 type sequence A description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 2) chain A residue 38 type sequence K description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 3) chain A residue 55 type sequence E description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 4) chain A residue 59 type sequence N description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 5) chain A residue 84 type sequence L description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 6) chain A residue 86 type sequence Y description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 7) chain A residue 87 type sequence C description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 8) chain A residue 90 type sequence G description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 9) chain A residue 91 type sequence E description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 10) chain A residue 94 type sequence D description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 11) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 12) chain A residue 148 type sequence D description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 13) chain A residue 149 type sequence F description BINDING SITE FOR RESIDUE 76A A 1001 source : AC1 14) chain A residue 130 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 15) chain A residue 132 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32357935 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 15-38 type prosite sequence LGEGAYGEVQLAVNRVTEEAVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAYGEVQlAvnrvteea..........VAVK source prosite : PS00107 17) chain A residue 126-138 type prosite sequence ITHRDIKPENLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ItHrDIKpeNLLL source prosite : PS00108 18) chain A residue 38 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 15 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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