eF-site ID 2dwc-AB PDB Code 2dwc Chain A, B click to enlarge Title Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP Classification TRANSFERASE Compound 433aa long hypothetical phosphoribosylglycinamide formyl transferase Source Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (O58056_PYRHO) Sequence A:  VVMIKLRDELGTATTDSAQKILLLGSGELGKEIAIEAQRL GVEVVAVDRYANAPAMQVAHRSYVGNMMDKDFLWSVVERE KPDAIIPEIEAINLDALFEFEKDGYFVVPNARATWIAMHR ERLRETLVKEAKVPTSRYMYATTLDELYEACEKIGYPCHT KAIMSYFVKGPEDIPKAWEEEKIIVEEHIDFDVEVTELAV RHFDENGEIVTTFPKPVGHYQIDGDYHASWQPAEISEKAE REVYRIAKRITDVLGGLGIFGVEMFVKGDKVWANEVSPRP HDTGMVTLASHPPGFSEFALHLRAVLGLPIPGEWVDGYRL FPMLIPAATHVIKAKVSGYSPRFRGLVKALSVPNATVRLF GKPEAYVGRRLGIALAWDKDVEVAKRKAEMVAHMIELRTR SSDWHD B:  VVMIKLRDELGTATTDSAQKILLLGSGELGKEIAIEAQRL GVEVVAVDRYANAPAMQVAHRSYVGNMMDKDFLWSVVERE KPDAIIPEIEAINLDALFEFEKDGYFVVPNARATWIAMHR ERLRETLVKEAKVPTSRYMYATTLDELYEACEKIGYPCHT KAIMSGSYFVKGPEDIPKAWEEEKIIVEEHIDFDVEVTEL AVRHFDENGEIVTTFPKPVGHYQIDGDYHASWQPAEISEK AEREVYRIAKRITDVLGGLGIFGVEMFVKGDKVWANEVSP RPHDTGMVTLASHPPGFSEFALHLRAVLGLPIPGEWVDGY RLFPMLIPAATHVIKAKVSGYSPRFRGLVKALSVPNATVR LFGKPEAYVGRRLGIALAWDKDVEVAKRKAEMVAHMIELR TRSSDWHDQ Description Functional site 1) chain B residue 378 type sequence K description BINDING SITE FOR RESIDUE SO4 B 601 source : AC1 2) chain B residue 382 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 601 source : AC1 3) chain B residue 385 type sequence R description BINDING SITE FOR RESIDUE SO4 B 601 source : AC1 4) chain A residue 414 type sequence R description BINDING SITE FOR RESIDUE SO4 A 602 source : AC2 5) chain A residue 420 type sequence W description BINDING SITE FOR RESIDUE SO4 A 602 source : AC2 6) chain B residue 414 type sequence R description BINDING SITE FOR RESIDUE SO4 B 603 source : AC3 7) chain B residue 420 type sequence W description BINDING SITE FOR RESIDUE SO4 B 603 source : AC3 8) chain A residue 378 type sequence K description BINDING SITE FOR RESIDUE SO4 A 604 source : AC4 9) chain A residue 382 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 604 source : AC4 10) chain A residue 385 type sequence R description BINDING SITE FOR RESIDUE SO4 A 604 source : AC4 11) chain A residue 121 type sequence R description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 12) chain A residue 160 type sequence H description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 13) chain A residue 162 type sequence K description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 14) chain A residue 202 type sequence E description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 15) chain A residue 203 type sequence E description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 16) chain A residue 204 type sequence H description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 17) chain A residue 205 type sequence I description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 18) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 19) chain A residue 210 type sequence E description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 20) chain A residue 237 type sequence Q description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 21) chain A residue 281 type sequence F description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 22) chain A residue 290 type sequence N description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 23) chain A residue 291 type sequence E description BINDING SITE FOR RESIDUE ADP A 501 source : AC5 24) chain B residue 121 type sequence R description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 25) chain B residue 160 type sequence H description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 26) chain B residue 162 type sequence K description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 27) chain B residue 202 type sequence E description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 28) chain B residue 203 type sequence E description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 29) chain B residue 204 type sequence H description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 30) chain B residue 205 type sequence I description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 31) chain B residue 207 type sequence F description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 32) chain B residue 210 type sequence E description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 33) chain B residue 237 type sequence Q description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 34) chain B residue 281 type sequence F description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 35) chain B residue 290 type sequence N description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 36) chain B residue 291 type sequence E description BINDING SITE FOR RESIDUE ADP B 502 source : AC6 37) chain A residue 26 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 279 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 291 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 298 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 378 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 385 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 86 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 276 type BINDING sequence F description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 288 type BINDING sequence W description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 295 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 375 type BINDING sequence L description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 382 type BINDING sequence Y description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 29 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 89 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01643 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 118 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 159 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 199 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 207 type BINDING sequence F description BINDING => ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 121 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 162 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 202 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 210 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01643, ECO:0000269|Ref.3 source Swiss-Prot : SWS_FT_FI2

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