eF-site ID 2dhh-A PDB Code 2dhh Chain A click to enlarge Title Crystal structure of a multidrug transporter reveal a functionally rotating mechanism Classification MEMBRANE PROTEIN Compound ACRB Source Escherichia coli (strain K12) (ACRB_ECOLI) Sequence A:  MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAP PAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSS NSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAA NMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTP VDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAE FNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSG LKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVL AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQG ALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL SVLVALILTPALCATMLKFGWFNRMFEKSTHHYTDSVGGI LRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMT MVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNG FGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRA FSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEK LTQARNQLLAEAAKHPDMLTSVRPNGLEDTPQFKIDIDQE KAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVM SEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSP RLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTG VGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYES WSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTT IGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAVRMRLRP ILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTA TVLAIFFVPVFFVVVRRRFSRK Description Functional site 1) chain A residue 872-888 type TRANSMEM sequence QAPSLYAISLIVVFLCL description Helical; Name=8 source Swiss-Prot : SWS_FT_FI10 2) chain A residue 899-918 type TRANSMEM sequence FSVMLVVPLGVIGALLAATF description Helical; Name=9 source Swiss-Prot : SWS_FT_FI11 3) chain A residue 925-943 type TRANSMEM sequence VYFQVGLLTTIGLSAKNAI description Helical; Name=10 source Swiss-Prot : SWS_FT_FI12 4) chain A residue 973-992 type TRANSMEM sequence RPILMTSLAFILGVMPLVIS description Helical; Name=11 source Swiss-Prot : SWS_FT_FI13 5) chain A residue 999-1018 type TRANSMEM sequence AQNAVGTGVMGGMVTATVLA description Helical; Name=12 source Swiss-Prot : SWS_FT_FI14 6) chain A residue 10-28 type TRANSMEM sequence IFAWVIAIIIMLAGGLAIL description Helical; Name=1 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 337-356 type TRANSMEM sequence IHEVVKTLVEAIILVFLVMY description Helical; Name=2 source Swiss-Prot : SWS_FT_FI4 8) chain A residue 366-385 type TRANSMEM sequence LIPTIAVPVVLLGTFAVLAA description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 9) chain A residue 392-413 type TRANSMEM sequence TLTMFGMVLAIGLLVDDAIVVV description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 10) chain A residue 439-457 type TRANSMEM sequence QGALVGIAMVLSAVFVPMA description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 11) chain A residue 466-490 type TRANSMEM sequence IYRQFSITIVSAMALSVLVALILTP description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 12) chain A residue 539-555 type TRANSMEM sequence GRYLVLYLIIVVGMAYL description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9 13) chain A residue 1-9 type TOPO_DOM sequence MPNFFIDRP description Cytoplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 357-365 type TOPO_DOM sequence LFLQNFRAT description Cytoplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 414-438 type TOPO_DOM sequence ENVERVMAEEGLPPKEATRKSMGQI description Cytoplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 491-538 type TOPO_DOM sequence ALCATMLKFGWFNRMFEKSTHHYTDSVGGILRST description Cytoplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 889-898 type TOPO_DOM sequence AALYESWSIP description Cytoplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 944-972 type TOPO_DOM sequence LIVEFAKDLMDKEGKGLIEATLDAVRMRL description Cytoplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 29-336 type TOPO_DOM sequence KLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQN MNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQ NKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGT MTQEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWM NPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQ QLNASIIAQTRLTSTEEFGKILLKVNQDGSRVLLRDVAKI ELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRA ELAKMEPFFPSGLKIVYPYDTTPFVKIS description Periplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 386-391 type TOPO_DOM sequence FGFSIN description Periplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 458-465 type TOPO_DOM sequence FFGGSTGA description Periplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 556-871 type TOPO_DOM sequence FVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVT HYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWA DRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELG TATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTS VRPNGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWG GSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAAD GQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGK STGEAMELMEQLASKLPTGVGYDWTGMSYQERLSGN description Periplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 919-924 type TOPO_DOM sequence RGLTND description Periplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 993-998 type TOPO_DOM sequence TGAGSG description Periplasmic => ECO:0000269|PubMed:15919996 source Swiss-Prot : SWS_FT_FI3

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