eF-site ID 2dhf-B PDB Code 2dhf Chain B click to enlarge Title CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source Homo sapiens (Human) (DYR_HUMAN) Sequence B:  LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSV EGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPP QGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYP GVLSDVQEEKGIKYKFEVYEKN Description Functional site 1) chain B residue 7 type sequence I description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 2) chain B residue 8 type sequence V description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 3) chain B residue 30 type sequence E description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 4) chain B residue 31 type sequence F description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 5) chain B residue 34 type sequence F description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 6) chain B residue 35 type sequence Q description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 7) chain B residue 64 type sequence N description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 8) chain B residue 70 type sequence R description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 9) chain B residue 115 type sequence V description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 10) chain B residue 121 type sequence Y description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 11) chain B residue 136 type sequence T description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 12) chain B residue 23 type catalytic sequence P description 490 source MCSA : MCSA2 13) chain B residue 31 type catalytic sequence F description 490 source MCSA : MCSA2 14) chain B residue 117 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 10 type BINDING sequence V description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 16 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 55 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 77 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 31 type BINDING sequence F description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 65 type BINDING sequence R description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 71 type BINDING sequence I description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2

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