eF-site ID 2dhf-AB PDB Code 2dhf Chain A, B click to enlarge Title CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE Classification OXIDOREDUCTASE Compound DIHYDROFOLATE REDUCTASE Source Homo sapiens (Human) (DYR_HUMAN) Sequence A:  LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSV EGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPP QGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYP GVLSDVQEEKGIKYKFEVYEKN B:  LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSV EGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPP QGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYP GVLSDVQEEKGIKYKFEVYEKN Description Functional site 1) chain A residue 7 type sequence I description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 2) chain A residue 8 type sequence V description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 3) chain A residue 9 type sequence A description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 4) chain A residue 22 type sequence L description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 5) chain A residue 30 type sequence E description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 6) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 7) chain A residue 34 type sequence F description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 8) chain A residue 35 type sequence Q description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 9) chain A residue 56 type sequence T description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 10) chain A residue 60 type sequence I description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 11) chain A residue 61 type sequence P description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 12) chain A residue 67 type sequence L description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 13) chain A residue 70 type sequence R description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 14) chain A residue 115 type sequence V description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 15) chain A residue 121 type sequence Y description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 16) chain A residue 136 type sequence T description BINDING SITE FOR RESIDUE DZF A 187 source : AC1 17) chain B residue 7 type sequence I description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 18) chain B residue 8 type sequence V description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 19) chain B residue 30 type sequence E description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 20) chain B residue 31 type sequence F description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 21) chain B residue 34 type sequence F description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 22) chain B residue 35 type sequence Q description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 23) chain B residue 64 type sequence N description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 24) chain B residue 70 type sequence R description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 25) chain B residue 115 type sequence V description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 26) chain B residue 121 type sequence Y description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 27) chain B residue 136 type sequence T description BINDING SITE FOR RESIDUE DZF B 187 source : AC2 28) chain A residue 23 type catalytic sequence P description 490 source MCSA : MCSA1 29) chain A residue 31 type catalytic sequence F description 490 source MCSA : MCSA1 30) chain B residue 23 type catalytic sequence P description 490 source MCSA : MCSA2 31) chain B residue 31 type catalytic sequence F description 490 source MCSA : MCSA2 32) chain A residue 10 type BINDING sequence V description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 117 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 16 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 55 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 77 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 117 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 10 type BINDING sequence V description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 16 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 55 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 77 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15039552, ECO:0000269|PubMed:16222560, ECO:0000269|PubMed:19478082 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 15-38 type prosite sequence GIGKNGDLPWPPLRNEFRYFQRMT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGkngdLPWpplrnEfryFqrmT source prosite : PS00075 43) chain A residue 31 type BINDING sequence F description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 65 type BINDING sequence R description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 71 type BINDING sequence I description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 46) chain B residue 31 type BINDING sequence F description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 65 type BINDING sequence R description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 71 type BINDING sequence I description BINDING => ECO:0000305|PubMed:2248959 source Swiss-Prot : SWS_FT_FI2

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