eF-site ID 2d4v-ABCD
PDB Code 2d4v
Chain A, B, C, D

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Title Crystal structure of NAD dependent isocitrate dehydrogenase from Acidithiobacillus thiooxidans
Classification OXIDOREDUCTASE
Compound isocitrate dehydrogenase
Source Thiobacillus thiooxidans (Q8GAX0_THITH)
Sequence A:  THIQKPATGSPLTLLNGVLQVPDQPIIPFIEGDGIGCDVT
PAMRSVVDAAVAKVYGGQRQIAWMELFAGQKAVQLYGEGQ
YLPDETMAAIREYKVAIKGPLETPVGGGIRSLNVAMRQDL
DLYVCLRPVRYFEGTPSPMRHPEKVDMVIFRENSEDIYAG
IEWPAGSPEAEKIIRFLREEMGVTKIRFPDSSAIGIKPVS
TEGSERLIRRTIQYALEHGKPSVSLVHKGNIMKFTEGGFR
DWGYALAEREFAGRVFTWRQKAAISKAEGKAAGQKAEQQA
IADGKLIIKDVIADNFLQQILLRPEDYSVVATLNLNGDYV
SDALAAEVGGIGMAPGANLSDTHAIFEATHGTAPDIAGQG
KANPSSLILSAVMMLEHLGWGEAAQAIVAAMNATIAAGEV
TGDLAALRGDVPALSTTEFTAALIRRF
B:  THIQKPATGSPLTLLNGVLQVPDQPIIPFIEGDGIGCDVT
PAMRSVVDAAVAKVYGGQRQIAWMELFAGQKAVQLYGEGQ
YLPDETMAAIREYKVAIKGPLETPVGGGIRSLNVAMRQDL
DLYVCLRPVRYFEGTPSPMRHPEKVDMVIFRENSEDIYAG
IEWPAGSPEAEKIIRFLREEMGVTKIRFPDSSAIGIKPVS
TEGSERLIRRTIQYALEHGKPSVSLVHKGNIMKFTEGGFR
DWGYALAEREFAGRVFTWRQKAAISKAEGKAAGQKAEQQA
IADGKLIIKDVIADNFLQQILLRPEDYSVVATLNLNGDYV
SDALAAEVGGIGMAPGANLSDTHAIFEATHGTAPDIAGQG
KANPSSLILSAVMMLEHLGWGEAAQAIVAAMNATIAAGEV
TGDLAALRGDVPALSTTEFTAALIRRF
C:  THIQKPATGSPLTLLNGVLQVPDQPIIPFIEGDGIGCDVT
PAMRSVVDAAVAKVYGGQRQIAWMELFAGQKAVQLYGEGQ
YLPDETMAAIREYKVAIKGPLETPVGGGIRSLNVAMRQDL
DLYVCLRPVRYFEGTPSPMRHPEKVDMVIFRENSEDIYAG
IEWPAGSPEAEKIIRFLREEMGVTKIRFPDSSAIGIKPVS
TEGSERLIRRTIQYALEHGKPSVSLVHKGNIMKFTEGGFR
DWGYALAEREFAGRVFTWRQKAAISKAEGKAAGQKAEQQA
IADGKLIIKDVIADNFLQQILLRPEDYSVVATLNLNGDYV
SDALAAEVGGIGMAPGANLSDTHAIFEATHGTAPDIAGQG
KANPSSLILSAVMMLEHLGWGEAAQAIVAAMNATIAAGEV
TGDLAALRGDVPALSTTEFTAALIRRF
D:  THIQKPATGSPLTLLNGVLQVPDQPIIPFIEGDGIGCDVT
PAMRSVVDAAVAKVYGGQRQIAWMELFAGQKAVQLYGEGQ
YLPDETMAAIREYKVAIKGPLETPVGGGIRSLNVAMRQDL
DLYVCLRPVRYFEGTPSPMRHPEKVDMVIFRENSEDIYAG
IEWPAGSPEAEKIIRFLREEMGVTKIRFPDSSAIGIKPVS
TEGSERLIRRTIQYALEHGKPSVSLVHKGNIMKFTEGGFR
DWGYALAEREFAGRVFTWRQKAAISKAEGKAAGQKAEQQA
IADGKLIIKDVIADNFLQQILLRPEDYSVVATLNLNGDYV
SDALAAEVGGIGMAPGANLSDTHAIFEATHGTAPDIAGQG
KANPSSLILSAVMMLEHLGWGEAAQAIVAAMNATIAAGEV
TGDLAALRGDVPALSTTEFTAALIRRF
Description


Functional site

1) chain A
residue 105
type
sequence T
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

2) chain A
residue 113
type
sequence S
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

3) chain A
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

4) chain A
residue 119
type
sequence R
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

5) chain A
residue 129
type
sequence R
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

6) chain A
residue 153
type
sequence R
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

7) chain A
residue 160
type
sequence Y
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

8) chain A
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

9) chain B
residue 230
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

10) chain B
residue 232
type
sequence N
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

11) chain B
residue 296
type
sequence D
description BINDING SITE FOR RESIDUE FLC A 3001
source : AC1

12) chain A
residue 230
type
sequence K
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

13) chain A
residue 232
type
sequence N
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

14) chain A
residue 233
type
sequence I
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

15) chain B
residue 105
type
sequence T
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

16) chain B
residue 113
type
sequence S
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

17) chain B
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

18) chain B
residue 119
type
sequence R
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

19) chain B
residue 129
type
sequence R
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

20) chain B
residue 153
type
sequence R
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

21) chain B
residue 160
type
sequence Y
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

22) chain B
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE FLC B 3101
source : AC2

23) chain C
residue 105
type
sequence T
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

24) chain C
residue 113
type
sequence S
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

25) chain C
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

26) chain C
residue 119
type
sequence R
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

27) chain C
residue 129
type
sequence R
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

28) chain C
residue 153
type
sequence R
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

29) chain C
residue 160
type
sequence Y
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

30) chain C
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

31) chain D
residue 230
type
sequence K
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

32) chain D
residue 232
type
sequence N
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

33) chain D
residue 233
type
sequence I
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

34) chain D
residue 296
type
sequence D
description BINDING SITE FOR RESIDUE FLC C 3201
source : AC3

35) chain C
residue 230
type
sequence K
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

36) chain C
residue 232
type
sequence N
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

37) chain C
residue 233
type
sequence I
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

38) chain C
residue 296
type
sequence D
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

39) chain D
residue 105
type
sequence T
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

40) chain D
residue 113
type
sequence S
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

41) chain D
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

42) chain D
residue 119
type
sequence R
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

43) chain D
residue 129
type
sequence R
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

44) chain D
residue 153
type
sequence R
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

45) chain D
residue 160
type
sequence Y
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

46) chain D
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE FLC D 3301
source : AC4

47) chain A
residue 37
type
sequence I
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

48) chain A
residue 100
type
sequence K
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

49) chain A
residue 102
type
sequence P
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

50) chain A
residue 103
type
sequence L
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

51) chain A
residue 104
type
sequence E
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

52) chain A
residue 105
type
sequence T
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

53) chain A
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

54) chain A
residue 333
type
sequence I
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

55) chain A
residue 349
type
sequence E
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

56) chain A
residue 351
type
sequence T
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

57) chain A
residue 352
type
sequence H
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

58) chain A
residue 353
type
sequence G
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

59) chain A
residue 354
type
sequence T
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

60) chain A
residue 355
type
sequence A
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

61) chain A
residue 357
type
sequence D
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

62) chain A
residue 364
type
sequence A
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

63) chain A
residue 365
type
sequence N
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

64) chain A
residue 405
type
sequence D
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

65) chain B
residue 232
type
sequence N
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

66) chain B
residue 294
type
sequence I
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

67) chain B
residue 297
type
sequence N
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

68) chain B
residue 300
type
sequence Q
description BINDING SITE FOR RESIDUE NAD A 2001
source : AC5

69) chain A
residue 232
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

70) chain A
residue 294
type
sequence I
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

71) chain A
residue 297
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

72) chain A
residue 300
type
sequence Q
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

73) chain B
residue 37
type
sequence I
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

74) chain B
residue 100
type
sequence K
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

75) chain B
residue 102
type
sequence P
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

76) chain B
residue 103
type
sequence L
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

77) chain B
residue 105
type
sequence T
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

78) chain B
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

79) chain B
residue 333
type
sequence I
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

80) chain B
residue 349
type
sequence E
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

81) chain B
residue 351
type
sequence T
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

82) chain B
residue 352
type
sequence H
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

83) chain B
residue 353
type
sequence G
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

84) chain B
residue 354
type
sequence T
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

85) chain B
residue 355
type
sequence A
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

86) chain B
residue 357
type
sequence D
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

87) chain B
residue 364
type
sequence A
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

88) chain B
residue 365
type
sequence N
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

89) chain B
residue 405
type
sequence D
description BINDING SITE FOR RESIDUE NAD B 2101
source : AC6

90) chain C
residue 37
type
sequence I
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

91) chain C
residue 100
type
sequence K
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

92) chain C
residue 102
type
sequence P
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

93) chain C
residue 103
type
sequence L
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

94) chain C
residue 104
type
sequence E
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

95) chain C
residue 105
type
sequence T
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

96) chain C
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

97) chain C
residue 333
type
sequence I
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

98) chain C
residue 349
type
sequence E
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

99) chain C
residue 351
type
sequence T
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

100) chain C
residue 352
type
sequence H
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

101) chain C
residue 353
type
sequence G
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

102) chain C
residue 354
type
sequence T
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

103) chain C
residue 355
type
sequence A
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

104) chain C
residue 357
type
sequence D
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

105) chain C
residue 364
type
sequence A
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

106) chain C
residue 365
type
sequence N
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

107) chain C
residue 405
type
sequence D
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

108) chain D
residue 232
type
sequence N
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

109) chain D
residue 294
type
sequence I
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

110) chain D
residue 297
type
sequence N
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

111) chain D
residue 300
type
sequence Q
description BINDING SITE FOR RESIDUE NAD C 2201
source : AC7

112) chain C
residue 232
type
sequence N
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

113) chain C
residue 294
type
sequence I
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

114) chain C
residue 297
type
sequence N
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

115) chain C
residue 300
type
sequence Q
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

116) chain D
residue 37
type
sequence I
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

117) chain D
residue 100
type
sequence K
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

118) chain D
residue 102
type
sequence P
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

119) chain D
residue 103
type
sequence L
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

120) chain D
residue 104
type
sequence E
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

121) chain D
residue 105
type
sequence T
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

122) chain D
residue 115
type
sequence N
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

123) chain D
residue 333
type
sequence I
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

124) chain D
residue 349
type
sequence E
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

125) chain D
residue 351
type
sequence T
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

126) chain D
residue 352
type
sequence H
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

127) chain D
residue 353
type
sequence G
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

128) chain D
residue 354
type
sequence T
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

129) chain D
residue 355
type
sequence A
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

130) chain D
residue 357
type
sequence D
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

131) chain D
residue 364
type
sequence A
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

132) chain D
residue 365
type
sequence N
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

133) chain D
residue 405
type
sequence D
description BINDING SITE FOR RESIDUE NAD D 2301
source : AC8

134) chain A
residue 316-335
type prosite
sequence NLNGDYVSDALAAEVGGIGM
description IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLNGDYvSDalAaev.GGIGM
source prosite : PS00470


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