eF-site ID 2d1k-ABC PDB Code 2d1k Chain A, B, C click to enlarge Title Ternary complex of the WH2 domain of mim with actin-dnase I Classification STRUCTURAL PROTEIN Compound Actin, alpha skeletal muscle Source ORGANISM_COMMON: rabbit; ORGANISM_SCIENTIFIC: Oryctolagus cuniculus; Sequence A:  ETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGV MVGMGQKDSYVGDEAQSKRGILTLKYPIEXGIITNWDDME KIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIM FETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNV PIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTT AEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELP DGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIM KCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPS TMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYD EAGPSIVHRKC B:  LKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQEV RDSHLVAVGKLLDYLNQDDPNTYHYVVSEPLGRNSYKERY LFLFRPNKVSVLDTYQYDDGCESCGNDSFSREPAVVKFSS HSTKVKEFAIVALHSAPSDAVAEINSLYDVYLDVQQKWHL NDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSA DTTATSTNCAYDRIVVAGSLLQSSVVPGSAAPFDFQAAYG LSNEMALAISDHYPVEVTLT C:  TPQGEDMLNAIRRGVKLKKTTTNDRSAPR Description Functional site 1) chain B residue 78 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:2395459 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 134 type ACT_SITE sequence H description ACT_SITE => ECO:0000269|PubMed:2395459, ECO:0000269|PubMed:4976790 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 47 type ACT_SITE sequence M description ACT_SITE => ECO:0000269|PubMed:2395459, ECO:0000269|PubMed:4976790 source Swiss-Prot : SWS_FT_FI2 4) chain B residue 67 type SITE sequence V description Involved in actin-binding => ECO:0000269|PubMed:2395459 source Swiss-Prot : SWS_FT_FI3 5) chain B residue 13 type SITE sequence E description Involved in actin-binding => ECO:0000269|PubMed:2395459 source Swiss-Prot : SWS_FT_FI3 6) chain B residue 65 type SITE sequence Y description Nitration by tetranitromethane destroys a Ca(2+) binding site and inactivates enzyme source Swiss-Prot : SWS_FT_FI4 7) chain B residue 18 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1748997, ECO:0000269|PubMed:3560229 source Swiss-Prot : SWS_FT_FI5 8) chain A residue 177 type MOD_RES sequence R description ADP-ribosylarginine; by SpvB => ECO:0000305|PubMed:16905096 source Swiss-Prot : SWS_FT_FI6 9) chain B residue 167-174 type prosite sequence GDFNADCS description DNASE_I_2 Deoxyribonuclease I signature 2. GDFNAdCS source prosite : PS00918 10) chain B residue 130-150 type prosite sequence IVALHSAPSDAVAEINSLYDV description DNASE_I_1 Deoxyribonuclease I signature 1. IVALHSAPsdavaEINsLyDV source prosite : PS00919 11) chain A residue 53-63 type prosite sequence YVGDEAQSKRG description ACTINS_1 Actins signature 1. YVGDEAQs.KRG source prosite : PS00406 12) chain A residue 356-364 type prosite sequence WITKQEYDE description ACTINS_2 Actins signature 2. WITKqEYDE source prosite : PS00432 13) chain A residue 104-116 type prosite sequence LLTEAPLNPKANR description ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR source prosite : PS01132 14) chain B residue 39 type catalytic sequence E description 41 source MCSA : MCSA1 15) chain B residue 76 type catalytic sequence Y description 41 source MCSA : MCSA1 16) chain B residue 78 type catalytic sequence E description 41 source MCSA : MCSA1 17) chain B residue 134 type catalytic sequence H description 41 source MCSA : MCSA1 18) chain B residue 168 type catalytic sequence D description 41 source MCSA : MCSA1 19) chain B residue 212 type catalytic sequence D description 41 source MCSA : MCSA1 20) chain B residue 252 type catalytic sequence H description 41 source MCSA : MCSA1

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