eF-site ID 2cw0-N
PDB Code 2cw0
Chain N

click to enlarge
Title Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution
Classification TRANSFERASE
Compound DNA-directed RNA polymerase alpha chain
Source ORGANISM_SCIENTIFIC: Thermus thermophilus;
Sequence N:  KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPER
DGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVT
KSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSAT
ELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYREL
RYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG
VALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEI
LAELPEPYLFGDKIVAAIDPEEEVIAEAEGVVHLHEPASI
LVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDVYG
RVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEAL
EKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMI
LEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNR
LKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTN
PGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVV
GPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAA
RRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGI
QAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSS
FAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYIT
QVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRE
TSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRL
ETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKD
LVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDD
AVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQIL
QLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQ
QIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFIS
SHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCG
TTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREV
EVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLT
CQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPG
TQLTMRTFHTGGVAGAADITQGLPRVIELFEARRPKAKAV
ISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLV
KDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQ
KVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQ
VLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKS
WLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIP
AGTGSDFVRFTQVVDQKTLKAIEEARKEAVEA
Description


Functional site

1) chain N
residue 58
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 1525
source : AC3

2) chain N
residue 60
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 1525
source : AC3

3) chain N
residue 73
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 1525
source : AC3

4) chain N
residue 76
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 1525
source : AC3

5) chain N
residue 1112
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 1526
source : AC4

6) chain N
residue 1194
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 1526
source : AC4

7) chain N
residue 1201
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 1526
source : AC4

8) chain N
residue 1204
type
sequence C
description BINDING SITE FOR RESIDUE ZN N 1526
source : AC4

9) chain N
residue 739
type
sequence D
description BINDING SITE FOR RESIDUE MG N 1527
source : AC6

10) chain N
residue 741
type
sequence D
description BINDING SITE FOR RESIDUE MG N 1527
source : AC6

11) chain N
residue 743
type
sequence D
description BINDING SITE FOR RESIDUE MG N 1527
source : AC6

12) chain N
residue 58
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

13) chain N
residue 60
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

14) chain N
residue 73
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

15) chain N
residue 76
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

16) chain N
residue 739
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

17) chain N
residue 741
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

18) chain N
residue 743
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

19) chain N
residue 1112
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

20) chain N
residue 1194
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

21) chain N
residue 1201
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

22) chain N
residue 1204
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1


Display surface

Download
Links