eF-site ID 2cls-AB PDB Code 2cls Chain A, B click to enlarge Title The crystal structure of the human RND1 GTPase in the active GTP bound state Classification NUCLEOTIDE BINDING PROTEIN Compound RHO-RELATED GTP-BINDING PROTEIN RHO6 Source Homo sapiens (Human) (RND1_HUMAN) Sequence A:  VVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFEN YTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVL LCFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDL RTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSA FTSEKSIHSIFRTASMLCL B:  VARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENY TACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLL CFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDLR TDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAF TSEKSIHSIFRTASMLCL Description Functional site 1) chain A residue 27 type sequence T description BINDING SITE FOR RESIDUE MG A 550 source : AC1 2) chain A residue 45 type sequence T description BINDING SITE FOR RESIDUE MG A 550 source : AC1 3) chain B residue 27 type sequence T description BINDING SITE FOR RESIDUE MG B 550 source : AC2 4) chain B residue 45 type sequence T description BINDING SITE FOR RESIDUE MG B 550 source : AC2 5) chain A residue 22 type sequence V description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 6) chain A residue 23 type sequence Q description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 7) chain A residue 24 type sequence C description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 8) chain A residue 25 type sequence G description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 9) chain A residue 26 type sequence K description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 10) chain A residue 27 type sequence T description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 11) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 12) chain A residue 38 type sequence Y description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 13) chain A residue 39 type sequence P description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 14) chain A residue 40 type sequence E description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 15) chain A residue 41 type sequence T description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 16) chain A residue 42 type sequence Y description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 17) chain A residue 45 type sequence T description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 18) chain A residue 69 type sequence S description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 19) chain A residue 70 type sequence G description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 20) chain A residue 126 type sequence K description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 21) chain A residue 128 type sequence D description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 22) chain A residue 129 type sequence L description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 23) chain A residue 168 type sequence S description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 24) chain A residue 169 type sequence A description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 25) chain A residue 170 type sequence F description BINDING SITE FOR RESIDUE GTP A 500 source : AC3 26) chain B residue 22 type sequence V description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 27) chain B residue 23 type sequence Q description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 28) chain B residue 24 type sequence C description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 29) chain B residue 25 type sequence G description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 30) chain B residue 26 type sequence K description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 31) chain B residue 27 type sequence T description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 32) chain B residue 28 type sequence A description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 33) chain B residue 38 type sequence Y description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 34) chain B residue 39 type sequence P description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 35) chain B residue 40 type sequence E description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 36) chain B residue 41 type sequence T description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 37) chain B residue 42 type sequence Y description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 38) chain B residue 45 type sequence T description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 39) chain B residue 69 type sequence S description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 40) chain B residue 70 type sequence G description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 41) chain B residue 126 type sequence K description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 42) chain B residue 128 type sequence D description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 43) chain B residue 129 type sequence L description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 44) chain B residue 168 type sequence S description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 45) chain B residue 169 type sequence A description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 46) chain B residue 170 type sequence F description BINDING SITE FOR RESIDUE GTP B 500 source : AC4 47) chain A residue 23 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 48) chain B residue 169 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 49) chain A residue 38 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 50) chain A residue 67 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 51) chain A residue 125 type BINDING sequence C description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 52) chain A residue 169 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 53) chain B residue 23 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 54) chain B residue 38 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 55) chain B residue 67 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1 56) chain B residue 125 type BINDING sequence C description BINDING => ECO:0000269|PubMed:19843518, ECO:0007744|PDB:2CLS source Swiss-Prot : SWS_FT_FI1

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