eF-site ID 2clp-K PDB Code 2clp Chain K click to enlarge Title Crystal structure of human aflatoxin B1 aldehyde reductase member 3 Classification OXIDOREDUCTASE Compound AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 Source (ARK73_HUMAN) Sequence K:  RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFV YSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKP DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAC HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK YKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILG MSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPN YFR Description Functional site 1) chain K residue 44 type sequence G description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 2) chain K residue 45 type sequence A description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 3) chain K residue 46 type sequence M description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 4) chain K residue 73 type sequence D description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 5) chain K residue 78 type sequence Y description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 6) chain K residue 142 type sequence H description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 7) chain K residue 172 type sequence S description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 8) chain K residue 173 type sequence N description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 9) chain K residue 198 type sequence Q description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 10) chain K residue 226 type sequence F description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 11) chain K residue 227 type sequence N description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 12) chain K residue 228 type sequence P description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 13) chain K residue 229 type sequence L description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 14) chain K residue 230 type sequence A description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 15) chain K residue 231 type sequence G description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 16) chain K residue 232 type sequence G description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 17) chain K residue 235 type sequence T description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 18) chain K residue 237 type sequence K description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 19) chain K residue 238 type sequence Y description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 20) chain K residue 250 type sequence G description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 21) chain K residue 251 type sequence R description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 22) chain K residue 293 type sequence T description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 23) chain K residue 315 type sequence I description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 24) chain K residue 317 type sequence G description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 25) chain K residue 318 type sequence M description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 26) chain K residue 319 type sequence S description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 27) chain K residue 323 type sequence Q description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 28) chain K residue 326 type sequence Q description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 29) chain K residue 327 type sequence N description BINDING SITE FOR RESIDUE NDP K 1361 source : BC6 30) chain K residue 142 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 31) chain K residue 198 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 32) chain K residue 261 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain K residue 264 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 34) chain K residue 106 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 35) chain K residue 114 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 36) chain K residue 78 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 37) chain K residue 73 type BINDING sequence D description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 38) chain K residue 172 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 39) chain K residue 227 type BINDING sequence N description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 40) chain K residue 251 type BINDING sequence R description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 41) chain K residue 319 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 42) chain K residue 256 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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