eF-site ID 2clp-J PDB Code 2clp Chain J click to enlarge Title Crystal structure of human aflatoxin B1 aldehyde reductase member 3 Classification OXIDOREDUCTASE Compound AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 Source (ARK73_HUMAN) Sequence J:  RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFV YSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKP DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAC HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK YKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILG MSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPN YFR Description Functional site 1) chain J residue 44 type sequence G description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 2) chain J residue 45 type sequence A description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 3) chain J residue 46 type sequence M description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 4) chain J residue 73 type sequence D description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 5) chain J residue 78 type sequence Y description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 6) chain J residue 142 type sequence H description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 7) chain J residue 172 type sequence S description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 8) chain J residue 173 type sequence N description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 9) chain J residue 198 type sequence Q description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 10) chain J residue 226 type sequence F description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 11) chain J residue 227 type sequence N description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 12) chain J residue 228 type sequence P description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 13) chain J residue 229 type sequence L description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 14) chain J residue 230 type sequence A description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 15) chain J residue 231 type sequence G description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 16) chain J residue 232 type sequence G description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 17) chain J residue 235 type sequence T description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 18) chain J residue 237 type sequence K description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 19) chain J residue 238 type sequence Y description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 20) chain J residue 250 type sequence G description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 21) chain J residue 251 type sequence R description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 22) chain J residue 261 type sequence Y description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 23) chain J residue 293 type sequence T description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 24) chain J residue 315 type sequence I description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 25) chain J residue 317 type sequence G description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 26) chain J residue 318 type sequence M description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 27) chain J residue 319 type sequence S description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 28) chain J residue 323 type sequence Q description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 29) chain J residue 326 type sequence Q description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 30) chain J residue 327 type sequence N description BINDING SITE FOR RESIDUE NDP J 1361 source : BC5 31) chain J residue 142 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 32) chain J residue 198 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain J residue 261 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 34) chain J residue 264 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 35) chain J residue 106 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 36) chain J residue 114 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 37) chain J residue 78 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 38) chain J residue 73 type BINDING sequence D description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 39) chain J residue 172 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 40) chain J residue 227 type BINDING sequence N description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 41) chain J residue 251 type BINDING sequence R description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 42) chain J residue 319 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 43) chain J residue 256 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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