eF-site ID 2clp-I PDB Code 2clp Chain I click to enlarge Title Crystal structure of human aflatoxin B1 aldehyde reductase member 3 Classification OXIDOREDUCTASE Compound AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 Source (ARK73_HUMAN) Sequence I:  PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVY SEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPD SLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACH QLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQ GMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKY KYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVE KALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGM SSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNY FR Description Functional site 1) chain I residue 44 type sequence G description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 2) chain I residue 45 type sequence A description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 3) chain I residue 46 type sequence M description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 4) chain I residue 73 type sequence D description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 5) chain I residue 78 type sequence Y description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 6) chain I residue 142 type sequence H description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 7) chain I residue 172 type sequence S description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 8) chain I residue 173 type sequence N description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 9) chain I residue 198 type sequence Q description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 10) chain I residue 226 type sequence F description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 11) chain I residue 227 type sequence N description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 12) chain I residue 228 type sequence P description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 13) chain I residue 229 type sequence L description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 14) chain I residue 231 type sequence G description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 15) chain I residue 232 type sequence G description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 16) chain I residue 235 type sequence T description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 17) chain I residue 237 type sequence K description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 18) chain I residue 238 type sequence Y description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 19) chain I residue 250 type sequence G description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 20) chain I residue 251 type sequence R description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 21) chain I residue 293 type sequence T description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 22) chain I residue 315 type sequence I description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 23) chain I residue 317 type sequence G description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 24) chain I residue 318 type sequence M description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 25) chain I residue 319 type sequence S description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 26) chain I residue 323 type sequence Q description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 27) chain I residue 326 type sequence Q description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 28) chain I residue 327 type sequence N description BINDING SITE FOR RESIDUE NDP I 1361 source : BC4 29) chain I residue 142 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 30) chain I residue 198 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 31) chain I residue 261 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 32) chain I residue 264 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain I residue 106 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 34) chain I residue 114 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 35) chain I residue 78 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 36) chain I residue 73 type BINDING sequence D description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 37) chain I residue 172 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 38) chain I residue 227 type BINDING sequence N description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 39) chain I residue 251 type BINDING sequence R description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 40) chain I residue 319 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 41) chain I residue 256 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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