eF-site ID 2clp-H PDB Code 2clp Chain H click to enlarge Title Crystal structure of human aflatoxin B1 aldehyde reductase member 3 Classification OXIDOREDUCTASE Compound AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 Source (ARK73_HUMAN) Sequence H:  RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFV YSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKP DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAC HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK YKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILG MSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPN YFR Description Functional site 1) chain H residue 44 type sequence G description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 2) chain H residue 46 type sequence M description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 3) chain H residue 51 type sequence R description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 4) chain H residue 73 type sequence D description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 5) chain H residue 78 type sequence Y description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 6) chain H residue 142 type sequence H description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 7) chain H residue 172 type sequence S description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 8) chain H residue 198 type sequence Q description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 9) chain H residue 226 type sequence F description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 10) chain H residue 227 type sequence N description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 11) chain H residue 228 type sequence P description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 12) chain H residue 229 type sequence L description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 13) chain H residue 230 type sequence A description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 14) chain H residue 231 type sequence G description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 15) chain H residue 232 type sequence G description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 16) chain H residue 235 type sequence T description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 17) chain H residue 237 type sequence K description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 18) chain H residue 238 type sequence Y description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 19) chain H residue 250 type sequence G description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 20) chain H residue 251 type sequence R description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 21) chain H residue 261 type sequence Y description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 22) chain H residue 293 type sequence T description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 23) chain H residue 315 type sequence I description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 24) chain H residue 317 type sequence G description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 25) chain H residue 318 type sequence M description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 26) chain H residue 319 type sequence S description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 27) chain H residue 323 type sequence Q description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 28) chain H residue 326 type sequence Q description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 29) chain H residue 327 type sequence N description BINDING SITE FOR RESIDUE NDP H 1361 source : BC3 30) chain H residue 142 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 31) chain H residue 198 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 32) chain H residue 261 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain H residue 264 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 34) chain H residue 106 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 35) chain H residue 114 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 36) chain H residue 78 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 37) chain H residue 73 type BINDING sequence D description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 38) chain H residue 172 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 39) chain H residue 227 type BINDING sequence N description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 40) chain H residue 251 type BINDING sequence R description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 41) chain H residue 319 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 42) chain H residue 256 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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