eF-site ID 2clp-G PDB Code 2clp Chain G click to enlarge Title Crystal structure of human aflatoxin B1 aldehyde reductase member 3 Classification OXIDOREDUCTASE Compound AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 Source (ARK73_HUMAN) Sequence G:  RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFV YSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKP DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAC HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK YKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILG MSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPN YFR Description Functional site 1) chain G residue 269 type sequence H description BINDING SITE FOR RESIDUE CA G 1362 source : AC4 2) chain G residue 272 type sequence E description BINDING SITE FOR RESIDUE CA G 1362 source : AC4 3) chain G residue 44 type sequence G description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 4) chain G residue 46 type sequence M description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 5) chain G residue 51 type sequence R description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 6) chain G residue 73 type sequence D description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 7) chain G residue 78 type sequence Y description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 8) chain G residue 106 type sequence K description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 9) chain G residue 142 type sequence H description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 10) chain G residue 172 type sequence S description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 11) chain G residue 173 type sequence N description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 12) chain G residue 198 type sequence Q description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 13) chain G residue 226 type sequence F description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 14) chain G residue 227 type sequence N description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 15) chain G residue 228 type sequence P description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 16) chain G residue 229 type sequence L description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 17) chain G residue 230 type sequence A description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 18) chain G residue 231 type sequence G description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 19) chain G residue 232 type sequence G description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 20) chain G residue 235 type sequence T description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 21) chain G residue 237 type sequence K description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 22) chain G residue 238 type sequence Y description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 23) chain G residue 250 type sequence G description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 24) chain G residue 251 type sequence R description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 25) chain G residue 315 type sequence I description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 26) chain G residue 317 type sequence G description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 27) chain G residue 319 type sequence S description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 28) chain G residue 323 type sequence Q description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 29) chain G residue 326 type sequence Q description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 30) chain G residue 327 type sequence N description BINDING SITE FOR RESIDUE NDP G 1361 source : BC2 31) chain G residue 78 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 32) chain G residue 73 type BINDING sequence D description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 33) chain G residue 172 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 34) chain G residue 227 type BINDING sequence N description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 35) chain G residue 251 type BINDING sequence R description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 36) chain G residue 319 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 37) chain G residue 142 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 38) chain G residue 198 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 39) chain G residue 261 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 40) chain G residue 264 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 41) chain G residue 106 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 42) chain G residue 114 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 43) chain G residue 256 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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