eF-site ID 2clp-F PDB Code 2clp Chain F click to enlarge Title Crystal structure of human aflatoxin B1 aldehyde reductase member 3 Classification OXIDOREDUCTASE Compound AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 Source (ARK73_HUMAN) Sequence F:  RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFV YSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKP DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAC HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK YKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILG MSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPN YFR Description Functional site 1) chain F residue 44 type sequence G description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 2) chain F residue 46 type sequence M description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 3) chain F residue 51 type sequence R description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 4) chain F residue 73 type sequence D description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 5) chain F residue 78 type sequence Y description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 6) chain F residue 142 type sequence H description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 7) chain F residue 172 type sequence S description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 8) chain F residue 173 type sequence N description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 9) chain F residue 198 type sequence Q description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 10) chain F residue 226 type sequence F description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 11) chain F residue 227 type sequence N description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 12) chain F residue 228 type sequence P description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 13) chain F residue 229 type sequence L description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 14) chain F residue 230 type sequence A description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 15) chain F residue 231 type sequence G description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 16) chain F residue 232 type sequence G description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 17) chain F residue 235 type sequence T description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 18) chain F residue 237 type sequence K description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 19) chain F residue 238 type sequence Y description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 20) chain F residue 250 type sequence G description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 21) chain F residue 251 type sequence R description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 22) chain F residue 315 type sequence I description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 23) chain F residue 317 type sequence G description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 24) chain F residue 318 type sequence M description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 25) chain F residue 319 type sequence S description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 26) chain F residue 323 type sequence Q description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 27) chain F residue 326 type sequence Q description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 28) chain F residue 327 type sequence N description BINDING SITE FOR RESIDUE NDP F 1361 source : BC1 29) chain F residue 78 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 30) chain F residue 73 type BINDING sequence D description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 31) chain F residue 172 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 32) chain F residue 227 type BINDING sequence N description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 33) chain F residue 251 type BINDING sequence R description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 34) chain F residue 319 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 35) chain F residue 261 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 36) chain F residue 264 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 37) chain F residue 142 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 38) chain F residue 198 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 39) chain F residue 106 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 40) chain F residue 114 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 41) chain F residue 256 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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