eF-site ID 2clp-D PDB Code 2clp Chain D click to enlarge Title Crystal structure of human aflatoxin B1 aldehyde reductase member 3 Classification OXIDOREDUCTASE Compound AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 Source (ARK73_HUMAN) Sequence D:  RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFV YSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKP DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAC HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK YKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILG MSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPN YFR Description Functional site 1) chain D residue 44 type sequence G description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 2) chain D residue 45 type sequence A description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 3) chain D residue 46 type sequence M description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 4) chain D residue 51 type sequence R description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 5) chain D residue 73 type sequence D description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 6) chain D residue 78 type sequence Y description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 7) chain D residue 106 type sequence K description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 8) chain D residue 142 type sequence H description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 9) chain D residue 172 type sequence S description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 10) chain D residue 173 type sequence N description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 11) chain D residue 198 type sequence Q description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 12) chain D residue 226 type sequence F description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 13) chain D residue 227 type sequence N description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 14) chain D residue 228 type sequence P description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 15) chain D residue 229 type sequence L description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 16) chain D residue 230 type sequence A description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 17) chain D residue 231 type sequence G description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 18) chain D residue 232 type sequence G description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 19) chain D residue 235 type sequence T description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 20) chain D residue 237 type sequence K description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 21) chain D residue 238 type sequence Y description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 22) chain D residue 250 type sequence G description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 23) chain D residue 251 type sequence R description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 24) chain D residue 315 type sequence I description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 25) chain D residue 317 type sequence G description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 26) chain D residue 318 type sequence M description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 27) chain D residue 319 type sequence S description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 28) chain D residue 323 type sequence Q description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 29) chain D residue 326 type sequence Q description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 30) chain D residue 327 type sequence N description BINDING SITE FOR RESIDUE NDP D 1361 source : AC8 31) chain D residue 78 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 32) chain D residue 73 type BINDING sequence D description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 33) chain D residue 172 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 34) chain D residue 227 type BINDING sequence N description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 35) chain D residue 251 type BINDING sequence R description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 36) chain D residue 319 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 37) chain D residue 142 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 38) chain D residue 198 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 39) chain D residue 261 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 40) chain D residue 264 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 41) chain D residue 106 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 42) chain D residue 114 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 43) chain D residue 256 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

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