eF-site ID 2clp-C PDB Code 2clp Chain C click to enlarge Title Crystal structure of human aflatoxin B1 aldehyde reductase member 3 Classification OXIDOREDUCTASE Compound AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 Source (ARK73_HUMAN) Sequence C:  RPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFV YSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKP DSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRAC HQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGK YKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALV EKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILG MSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPN YFR Description Functional site 1) chain C residue 269 type sequence H description BINDING SITE FOR RESIDUE CA C 1362 source : AC2 2) chain C residue 272 type sequence E description BINDING SITE FOR RESIDUE CA C 1362 source : AC2 3) chain C residue 44 type sequence G description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 4) chain C residue 45 type sequence A description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 5) chain C residue 46 type sequence M description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 6) chain C residue 51 type sequence R description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 7) chain C residue 73 type sequence D description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 8) chain C residue 78 type sequence Y description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 9) chain C residue 142 type sequence H description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 10) chain C residue 172 type sequence S description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 11) chain C residue 173 type sequence N description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 12) chain C residue 198 type sequence Q description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 13) chain C residue 226 type sequence F description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 14) chain C residue 227 type sequence N description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 15) chain C residue 228 type sequence P description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 16) chain C residue 229 type sequence L description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 17) chain C residue 230 type sequence A description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 18) chain C residue 231 type sequence G description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 19) chain C residue 232 type sequence G description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 20) chain C residue 235 type sequence T description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 21) chain C residue 237 type sequence K description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 22) chain C residue 238 type sequence Y description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 23) chain C residue 250 type sequence G description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 24) chain C residue 251 type sequence R description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 25) chain C residue 315 type sequence I description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 26) chain C residue 317 type sequence G description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 27) chain C residue 318 type sequence M description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 28) chain C residue 319 type sequence S description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 29) chain C residue 323 type sequence Q description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 30) chain C residue 326 type sequence Q description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 31) chain C residue 327 type sequence N description BINDING SITE FOR RESIDUE NDP C 1361 source : AC7 32) chain C residue 78 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 33) chain C residue 73 type BINDING sequence D description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 34) chain C residue 172 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 35) chain C residue 227 type BINDING sequence N description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 36) chain C residue 251 type BINDING sequence R description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 37) chain C residue 319 type BINDING sequence S description BINDING => ECO:0000269|Ref.7 source Swiss-Prot : SWS_FT_FI2 38) chain C residue 198 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 39) chain C residue 261 type BINDING sequence Y description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 40) chain C residue 264 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 41) chain C residue 142 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 42) chain C residue 106 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 43) chain C residue 114 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI6 44) chain C residue 256 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI7

Display surface Download Links