eF-site ID 2cik-ABC PDB Code 2cik Chain A, B, C click to enlarge Title Insights Into Crossreactivity in Human Allorecognition: The Structure of HLA-B35011 Presenting an Epitope derived from Cytochrome P450. Classification IMMUNE SYSTEM/PEPTIDE Compound HLA CLASS I HISTOCOMPATIBILITY ANTIGEN B-35 ALPHA CHAIN Source Homo sapiens (Human) (2CIK) Sequence A:  GSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDA ASPRTEPRAPWIEQEGPEYWDRNTQIFKTNTQTYRESLRN LRGYYNQSEAGSHIIQRMYGCDLGPDGRLLRGHDQSAYDG KDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYL EGLCVEWLRRYLENGKETLQRADPPKTHVTHHPVSDHEAT LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRT FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP B:  IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC RVNHVTLSQPKIVKWDRDM C:  KPIVVLHGY Description Functional site 1) chain A residue 6 type sequence R description BINDING SITE FOR RESIDUE GOL A1277 source : AC1 2) chain A residue 8 type sequence F description BINDING SITE FOR RESIDUE GOL A1277 source : AC1 3) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE GOL A1277 source : AC1 4) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE GOL A1277 source : AC1 5) chain B residue 63 type sequence Y description BINDING SITE FOR RESIDUE GOL A1277 source : AC1 6) chain B residue 33 type sequence S description BINDING SITE FOR RESIDUE GOL B1100 source : AC2 7) chain B residue 34 type sequence D description BINDING SITE FOR RESIDUE GOL B1100 source : AC2 8) chain A residue 206 type sequence L description BINDING SITE FOR RESIDUE GOL B1101 source : AC3 9) chain A residue 234 type sequence R description BINDING SITE FOR RESIDUE GOL B1101 source : AC3 10) chain A residue 242 type sequence Q description BINDING SITE FOR RESIDUE GOL B1101 source : AC3 11) chain B residue 10 type sequence Y description BINDING SITE FOR RESIDUE GOL B1101 source : AC3 12) chain B residue 11 type sequence S description BINDING SITE FOR RESIDUE GOL B1101 source : AC3 13) chain B residue 13 type sequence H description BINDING SITE FOR RESIDUE GOL B1101 source : AC3 14) chain B residue 14 type sequence P description BINDING SITE FOR RESIDUE GOL B1101 source : AC3 15) chain B residue 97 type sequence R description BINDING SITE FOR RESIDUE GOL B1101 source : AC3 16) chain B residue 2 type MOD_RES sequence Q description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 84 type MOD_RES sequence Y description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 143 type MOD_RES sequence T description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 146 type MOD_RES sequence K description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 152 type MOD_RES sequence V description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 159 type MOD_RES sequence Y description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 171 type MOD_RES sequence Y description Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 257-263 type prosite sequence YTCHVQH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH source prosite : PS00290 24) chain B residue 78-84 type prosite sequence YACRVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH source prosite : PS00290 25) chain B residue 1 type CARBOHYD sequence I description N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 19 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 27) chain B residue 41 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 48 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 29) chain B residue 58 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 91 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 94 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3

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