eF-site ID 2cha-ABCEFG PDB Code 2cha Chain A, B, C, E, F, G click to enlarge Title THE STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN, $V.THE ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 ANGSTROMS RESOLUTION Classification HYDROLASE (SERINE PROTEINASE) Compound ALPHA-CHYMOTRYPSIN A Source ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; Sequence A:  CGVPAIQPV B:  IVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTA AHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYN SLTINNDITLLKLSTAASFSQTVSAVCLPSASDDFAAGTT CVTTGWGLTRY C:  ANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGV SSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVY ARVTALVNWVQQTLAAN E:  CGVPAIQPV F:  IVNGEEAVPGSWPWQVSLQDKTGFHFCGGSLINENWVVTA AHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYN SLTINNDITLLKLSTAASFSQTVSAVCLPSASDDFAAGTT CVTTGWGLTRY G:  ANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGV SSCMGDSGGPLVCKKNGAWTLVGIVSWGSSTCSTSTPGVY ARVTALVNWVQQTLAAN Description Functional site 1) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 2) chain C residue 190 type sequence S description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 3) chain C residue 191 type sequence C description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 4) chain C residue 192 type sequence M description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 5) chain C residue 193 type sequence G description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 6) chain C residue 194 type sequence D description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 7) chain C residue 195 type sequence S description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 8) chain C residue 216 type sequence G description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 9) chain F residue 146 type sequence Y description BINDING SITE FOR RESIDUE TSU C 51 source : AC1 10) chain B residue 146 type sequence Y description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 11) chain F residue 57 type sequence H description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 12) chain G residue 190 type sequence S description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 13) chain G residue 191 type sequence C description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 14) chain G residue 192 type sequence M description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 15) chain G residue 193 type sequence G description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 16) chain G residue 194 type sequence D description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 17) chain G residue 195 type sequence S description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 18) chain G residue 216 type sequence G description BINDING SITE FOR RESIDUE TSU G 51 source : AC2 19) chain C residue 193 type catalytic sequence G description 387 source MCSA : MCSA1 20) chain C residue 195 type catalytic sequence S description 387 source MCSA : MCSA1 21) chain C residue 196 type catalytic sequence G description 387 source MCSA : MCSA1 22) chain G residue 193 type catalytic sequence G description 387 source MCSA : MCSA2 23) chain G residue 195 type catalytic sequence S description 387 source MCSA : MCSA2 24) chain G residue 196 type catalytic sequence G description 387 source MCSA : MCSA2 25) chain C residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 26) chain G residue 195 type ACT_SITE sequence S description Charge relay system source Swiss-Prot : SWS_FT_FI1 27) chain F residue 57 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI1 28) chain F residue 102 type ACT_SITE sequence D description Charge relay system source Swiss-Prot : SWS_FT_FI1 29) chain B residue 53-58 type prosite sequence VTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC source prosite : PS00134 30) chain C residue 189-200 type prosite sequence SSCMGDSGGPLV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. SScmGDSGGPLV source prosite : PS00135

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