eF-site ID 2cfl-A PDB Code 2cfl Chain A click to enlarge Title AGAO in complex with wc6b (Ru-wire inhibitor, 6-carbon linker, data set b) Classification OXIDOREDUCTASE Compound PHENYLETHYLAMINE OXIDASE Source (2CFL) Sequence A:  ASPFRLASAGEISEVQGILRTAGLLGPEKRIAYLGVLDPA RGAGSEAEDRRFRVFIHDVSGARPQEVTVSVTNGTVISAV ELDTAATGELPVLEEEFEVVEQLLATDERWLKALAARNLD VSKVRVAPLSAGVFEYAEERGRRILRGLAFVQDFPEDSAW AHPVDGLVAYVDVVSKEVTRVIDTGVFPVPAEHGNYTDPE LTGPLRTTQKPISITQPEGPSFTVTGGNHIEWEKWSLDVG FDVREGVVLHNIAFRDGDRLRPIINRASIAEMVVPYGDPS PIRSWQNYFDTGEYLVGQYANSLELGCDCLGDITYLSPVI SDAFGNPREIRNGICMHEEDWGILAKHSDLWSGINYTRRN RRMVISFFTTIGNXDYGFYWYLYLDGTIEFEAKATGVVFT SAFPEGGSDNISQLAPGLGAPFHQHIFSARLDMAIDGFTN RVEEEDVVRQTMGPGNERGNAFSRKRTVLTRESEAVREAD ARTGRTWIISNPESKNRLNEPVGYKLHAHNQPTLLADPGS SIARRAAFATKDLWVTRYADDERYPTGDFVNQHSGGAGLP SYIAQDRDIDGQDIVVWHTFGLTHFPRVEDWPIMPVDTVG FKLRPEGFFDRSPVLDVPAN Description (1)  PHENYLETHYLAMINE OXIDASE (E.C.1.4.3.6) Functional site 1) chain A residue 431 type sequence H description BINDING SITE FOR RESIDUE CU A1629 source : AC1 2) chain A residue 433 type sequence H description BINDING SITE FOR RESIDUE CU A1629 source : AC1 3) chain A residue 592 type sequence H description BINDING SITE FOR RESIDUE CU A1629 source : AC1 4) chain A residue 440 type sequence D description BINDING SITE FOR RESIDUE NA A1630 source : AC2 5) chain A residue 441 type sequence M description BINDING SITE FOR RESIDUE NA A1630 source : AC2 6) chain A residue 581 type sequence D description BINDING SITE FOR RESIDUE NA A1630 source : AC2 7) chain A residue 582 type sequence I description BINDING SITE FOR RESIDUE NA A1630 source : AC2 8) chain A residue 316 type sequence D description BINDING SITE FOR RESIDUE SO4 A1632 source : AC3 9) chain A residue 317 type sequence C description BINDING SITE FOR RESIDUE SO4 A1632 source : AC3 10) chain A residue 318 type sequence L description BINDING SITE FOR RESIDUE SO4 A1632 source : AC3 11) chain A residue 345 type sequence H description BINDING SITE FOR RESIDUE SO4 A1632 source : AC3 12) chain A residue 350 type sequence G description BINDING SITE FOR RESIDUE SO4 A1632 source : AC3 13) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE SO4 A1632 source : AC3 14) chain A residue 233 type sequence T description BINDING SITE FOR RESIDUE SO4 A1633 source : AC4 15) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE SO4 A1633 source : AC4 16) chain A residue 545 type sequence R description BINDING SITE FOR RESIDUE SO4 A1634 source : AC5 17) chain A residue 576 type sequence D description BINDING SITE FOR RESIDUE SO4 A1634 source : AC5 18) chain A residue 102 type sequence E description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 19) chain A residue 105 type sequence F description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 20) chain A residue 135 type sequence A description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 21) chain A residue 136 type sequence P description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 22) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 23) chain A residue 296 type sequence Y description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 24) chain A residue 302 type sequence Y description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 25) chain A residue 357 type sequence D description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 26) chain A residue 358 type sequence L description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 27) chain A residue 361 type sequence G description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 28) chain A residue 363 type sequence N description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 29) chain A residue 380 type sequence G description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 30) chain A residue 381 type sequence N description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 31) chain A residue 382 type sequence X description BINDING SITE FOR RESIDUE R6A A1631 source : AC6 32) chain A residue 532 type sequence R description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 33) chain A residue 533 type sequence R description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 34) chain A residue 554 type sequence T description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 35) chain A residue 557 type sequence F description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 36) chain A residue 561 type sequence H description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 37) chain A residue 562 type sequence S description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 38) chain A residue 563 type sequence G description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 39) chain A residue 564 type sequence G description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 40) chain A residue 565 type sequence A description BINDING SITE FOR RESIDUE GOL A1635 source : AC7 41) chain A residue 126 type sequence N description BINDING SITE FOR RESIDUE GOL A1636 source : AC8 42) chain A residue 159 type sequence V description BINDING SITE FOR RESIDUE GOL A1636 source : AC8 43) chain A residue 161 type sequence D description BINDING SITE FOR RESIDUE GOL A1636 source : AC8 44) chain A residue 197 type sequence V description BINDING SITE FOR RESIDUE GOL A1636 source : AC8 45) chain A residue 199 type sequence A description BINDING SITE FOR RESIDUE GOL A1636 source : AC8 46) chain A residue 444 type sequence D description BINDING SITE FOR RESIDUE GOL A1637 source : AC9 47) chain A residue 445 type sequence G description BINDING SITE FOR RESIDUE GOL A1637 source : AC9 48) chain A residue 446 type sequence F description BINDING SITE FOR RESIDUE GOL A1637 source : AC9 49) chain A residue 447 type sequence T description BINDING SITE FOR RESIDUE GOL A1637 source : AC9 50) chain A residue 499 type sequence N description BINDING SITE FOR RESIDUE GOL A1637 source : AC9 51) chain A residue 210 type sequence T description BINDING SITE FOR RESIDUE GOL A1638 source : BC1 52) chain A residue 620 type sequence S description BINDING SITE FOR RESIDUE GOL A1638 source : BC1 53) chain A residue 621 type sequence P description BINDING SITE FOR RESIDUE GOL A1638 source : BC1 54) chain A residue 622 type sequence V description BINDING SITE FOR RESIDUE GOL A1638 source : BC1 55) chain A residue 623 type sequence L description BINDING SITE FOR RESIDUE GOL A1638 source : BC1 56) chain A residue 347 type sequence E description BINDING SITE FOR RESIDUE GOL A1639 source : BC2 57) chain A residue 370 type sequence R description BINDING SITE FOR RESIDUE GOL A1639 source : BC2 58) chain A residue 401 type sequence K description BINDING SITE FOR RESIDUE GOL A1639 source : BC2 59) chain A residue 298 type ACT_SITE sequence D description Proton acceptor => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 382 type ACT_SITE sequence X description Schiff-base intermediate with substrate; via topaquinone => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 296 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI3 62) chain A residue 379 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P46883 source Swiss-Prot : SWS_FT_FI4 63) chain A residue 371-384 type prosite sequence MVISFFTTIGNXDY description COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. MVIsfftTigNYDY source prosite : PS01164 64) chain A residue 587-600 type prosite sequence TFGLTHFPRVEDWP description COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TfGltHFprvEDwP source prosite : PS01165 65) chain A residue 382 type MOD_RES sequence X description 2',4',5'-topaquinone => ECO:0000269|PubMed:9405045 source Swiss-Prot : SWS_FT_FI6 66) chain A residue 433 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5 67) chain A residue 592 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5 68) chain A residue 431 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5

Display surface Download Links