eF-site ID 2cfk-A PDB Code 2cfk Chain A click to enlarge Title AGAO in complex with wc5 (Ru-wire inhibitor, 5-carbon linker) Classification OXIDOREDUCTASE Compound PHENYLETHYLAMINE OXIDASE Source (2CFK) Sequence A:  ASPFRLASAGEISEVQGILRTAGLLGPEKRIAYLGVLDPA RGAGSEAEDRRFRVFIHDVSGARPQEVTVSVTNGTVISAV ELDTAATGELPVLEEEFEVVEQLLATDERWLKALAARNLD VSKVRVAPLSAGVFEYAEERGRRILRGLAFVQDFPEDSAW AHPVDGLVAYVDVVSKEVTRVIDTGVFPVPAEHGNYTDPE LTGPLRTTQKPISITQPEGPSFTVTGGNHIEWEKWSLDVG FDVREGVVLHNIAFRDGDRLRPIINRASIAEMVVPYGDPS PIRSWQNYFDTGEYLVGQYANSLELGCDCLGDITYLSPVI SDAFGNPREIRNGICMHEEDWGILAKHSDLWSGINYTRRN RRMVISFFTTIGNXDYGFYWYLYLDGTIEFEAKATGVVFT SAFPEGGSDNISQLAPGLGAPFHQHIFSARLDMAIDGFTN RVEEEDVVRQTMGPGNERGNAFSRKRTVLTRESEAVREAD ARTGRTWIISNPESKNRLNEPVGYKLHAHNQPTLLADPGS SIARRAAFATKDLWVTRYADDERYPTGDFVNQHSGGAGLP SYIAQDRDIDGQDIVVWHTFGLTHFPRVEDWPIMPVDTVG FKLRPEGFFDRSPVLDVPAN Description Functional site 1) chain A residue 431 type sequence H description BINDING SITE FOR RESIDUE CU A1629 source : AC1 2) chain A residue 433 type sequence H description BINDING SITE FOR RESIDUE CU A1629 source : AC1 3) chain A residue 592 type sequence H description BINDING SITE FOR RESIDUE CU A1629 source : AC1 4) chain A residue 440 type sequence D description BINDING SITE FOR RESIDUE NA A1630 source : AC2 5) chain A residue 441 type sequence M description BINDING SITE FOR RESIDUE NA A1630 source : AC2 6) chain A residue 581 type sequence D description BINDING SITE FOR RESIDUE NA A1630 source : AC2 7) chain A residue 582 type sequence I description BINDING SITE FOR RESIDUE NA A1630 source : AC2 8) chain A residue 233 type sequence T description BINDING SITE FOR RESIDUE SO4 A1633 source : AC3 9) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE SO4 A1633 source : AC3 10) chain A residue 545 type sequence R description BINDING SITE FOR RESIDUE SO4 A1634 source : AC4 11) chain A residue 576 type sequence D description BINDING SITE FOR RESIDUE SO4 A1634 source : AC4 12) chain A residue 316 type sequence D description BINDING SITE FOR RESIDUE SO4 A1642 source : AC5 13) chain A residue 317 type sequence C description BINDING SITE FOR RESIDUE SO4 A1642 source : AC5 14) chain A residue 318 type sequence L description BINDING SITE FOR RESIDUE SO4 A1642 source : AC5 15) chain A residue 345 type sequence H description BINDING SITE FOR RESIDUE SO4 A1642 source : AC5 16) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE SO4 A1642 source : AC5 17) chain A residue 102 type sequence E description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 18) chain A residue 105 type sequence F description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 19) chain A residue 135 type sequence A description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 20) chain A residue 136 type sequence P description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 21) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 22) chain A residue 168 type sequence W description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 23) chain A residue 296 type sequence Y description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 24) chain A residue 302 type sequence Y description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 25) chain A residue 307 type sequence Y description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 26) chain A residue 358 type sequence L description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 27) chain A residue 378 type sequence T description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 28) chain A residue 380 type sequence G description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 29) chain A residue 381 type sequence N description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 30) chain A residue 382 type sequence X description BINDING SITE FOR RESIDUE R5A A1631 source : AC6 31) chain A residue 102 type sequence E description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 32) chain A residue 105 type sequence F description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 33) chain A residue 106 type sequence E description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 34) chain A residue 135 type sequence A description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 35) chain A residue 136 type sequence P description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 36) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 37) chain A residue 168 type sequence W description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 38) chain A residue 296 type sequence Y description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 39) chain A residue 302 type sequence Y description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 40) chain A residue 336 type sequence R description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 41) chain A residue 358 type sequence L description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 42) chain A residue 380 type sequence G description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 43) chain A residue 381 type sequence N description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 44) chain A residue 382 type sequence X description BINDING SITE FOR RESIDUE R5B A1632 source : AC7 45) chain A residue 532 type sequence R description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 46) chain A residue 533 type sequence R description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 47) chain A residue 554 type sequence T description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 48) chain A residue 557 type sequence F description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 49) chain A residue 561 type sequence H description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 50) chain A residue 562 type sequence S description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 51) chain A residue 563 type sequence G description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 52) chain A residue 564 type sequence G description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 53) chain A residue 565 type sequence A description BINDING SITE FOR RESIDUE GOL A1635 source : AC8 54) chain A residue 126 type sequence N description BINDING SITE FOR RESIDUE GOL A1636 source : AC9 55) chain A residue 159 type sequence V description BINDING SITE FOR RESIDUE GOL A1636 source : AC9 56) chain A residue 161 type sequence D description BINDING SITE FOR RESIDUE GOL A1636 source : AC9 57) chain A residue 197 type sequence V description BINDING SITE FOR RESIDUE GOL A1636 source : AC9 58) chain A residue 199 type sequence A description BINDING SITE FOR RESIDUE GOL A1636 source : AC9 59) chain A residue 605 type sequence D description BINDING SITE FOR RESIDUE GOL A1637 source : BC1 60) chain A residue 610 type sequence K description BINDING SITE FOR RESIDUE GOL A1637 source : BC1 61) chain A residue 612 type sequence R description BINDING SITE FOR RESIDUE GOL A1637 source : BC1 62) chain A residue 444 type sequence D description BINDING SITE FOR RESIDUE GOL A1638 source : BC2 63) chain A residue 445 type sequence G description BINDING SITE FOR RESIDUE GOL A1638 source : BC2 64) chain A residue 446 type sequence F description BINDING SITE FOR RESIDUE GOL A1638 source : BC2 65) chain A residue 447 type sequence T description BINDING SITE FOR RESIDUE GOL A1638 source : BC2 66) chain A residue 499 type sequence N description BINDING SITE FOR RESIDUE GOL A1638 source : BC2 67) chain A residue 209 type sequence L description BINDING SITE FOR RESIDUE GOL A1639 source : BC3 68) chain A residue 210 type sequence T description BINDING SITE FOR RESIDUE GOL A1639 source : BC3 69) chain A residue 620 type sequence S description BINDING SITE FOR RESIDUE GOL A1639 source : BC3 70) chain A residue 621 type sequence P description BINDING SITE FOR RESIDUE GOL A1639 source : BC3 71) chain A residue 622 type sequence V description BINDING SITE FOR RESIDUE GOL A1639 source : BC3 72) chain A residue 623 type sequence L description BINDING SITE FOR RESIDUE GOL A1639 source : BC3 73) chain A residue 347 type sequence E description BINDING SITE FOR RESIDUE GOL A1640 source : BC4 74) chain A residue 370 type sequence R description BINDING SITE FOR RESIDUE GOL A1640 source : BC4 75) chain A residue 401 type sequence K description BINDING SITE FOR RESIDUE GOL A1640 source : BC4 76) chain A residue 368 type sequence N description BINDING SITE FOR RESIDUE GOL A1641 source : BC5 77) chain A residue 391 type sequence Y description BINDING SITE FOR RESIDUE GOL A1641 source : BC5 78) chain A residue 393 type sequence D description BINDING SITE FOR RESIDUE GOL A1641 source : BC5 79) chain A residue 610 type sequence K description BINDING SITE FOR RESIDUE GOL A1641 source : BC5 80) chain A residue 298 type ACT_SITE sequence D description Proton acceptor => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI1 81) chain A residue 382 type ACT_SITE sequence X description Schiff-base intermediate with substrate; via topaquinone => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI2 82) chain A residue 431 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5 83) chain A residue 433 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5 84) chain A residue 592 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5 85) chain A residue 371-384 type prosite sequence MVISFFTTIGNXDY description COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. MVIsfftTigNYDY source prosite : PS01164 86) chain A residue 587-600 type prosite sequence TFGLTHFPRVEDWP description COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TfGltHFprvEDwP source prosite : PS01165 87) chain A residue 296 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI3 88) chain A residue 379 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P46883 source Swiss-Prot : SWS_FT_FI4 89) chain A residue 382 type MOD_RES sequence X description 2',4',5'-topaquinone => ECO:0000269|PubMed:9405045 source Swiss-Prot : SWS_FT_FI6

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