eF-site ID 2cfi-A PDB Code 2cfi Chain A click to enlarge Title The hydrolase domain of human 10-FTHFD in complex with 6- formyltetrahydropterin Classification OXIDOREDUCTASE Compound 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE Source Homo sapiens (Human) (FTHFD_HUMAN) Sequence A:  FQSMKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDG KADPLGLEAEKDGVPVFKYSRWRAKGQALPDVVAKYQALG AELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGAS AINWTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPD DTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEEG ATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEA CEQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGL ILFGNDDKMLLVKNIQLEDGKMILASNFFK Description Functional site 1) chain A residue 112 type sequence R description BINDING SITE FOR RESIDUE SO4 A1308 source : AC1 2) chain A residue 128 type sequence K description BINDING SITE FOR RESIDUE SO4 A1308 source : AC1 3) chain A residue 129 type sequence K description BINDING SITE FOR RESIDUE SO4 A1308 source : AC1 4) chain A residue 60 type sequence R description BINDING SITE FOR RESIDUE SO4 A1309 source : AC2 5) chain A residue 89 type sequence F description BINDING SITE FOR RESIDUE SO4 A1309 source : AC2 6) chain A residue 264 type sequence P description BINDING SITE FOR RESIDUE SO4 A1309 source : AC2 7) chain A residue 265 type sequence G description BINDING SITE FOR RESIDUE SO4 A1309 source : AC2 8) chain A residue 112 type sequence R description BINDING SITE FOR RESIDUE SO4 A1310 source : AC3 9) chain A residue 197 type sequence G description BINDING SITE FOR RESIDUE SO4 A1310 source : AC3 10) chain A residue 86 type sequence C description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 11) chain A residue 87 type sequence S description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 12) chain A residue 88 type sequence Q description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 13) chain A residue 89 type sequence F description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 14) chain A residue 90 type sequence I description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 15) chain A residue 95 type sequence I description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 16) chain A residue 104 type sequence I description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 17) chain A residue 135 type sequence F description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 18) chain A residue 138 type sequence D description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 19) chain A residue 140 type sequence G description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 20) chain A residue 142 type sequence D description BINDING SITE FOR RESIDUE ZZZ A1311 source : AC4 21) chain A residue 131-154 type prosite sequence GFSIFWADDGLDTGDLLLQKECEV description GART Phosphoribosylglycinamide formyltransferase active site. GfSIfWAdDgLDtGdlLlqkeceV source prosite : PS00373 22) chain A residue 106 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:P28037 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 88 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:17057331, ECO:0007744|PDB:2CFI source Swiss-Prot : SWS_FT_FI2 24) chain A residue 142 type BINDING sequence D description BINDING => ECO:0000305|PubMed:17057331, ECO:0007744|PDB:2CFI source Swiss-Prot : SWS_FT_FI2 25) chain A residue 142 type SITE sequence D description Essential for catalytic activity => ECO:0000250|UniProtKB:P28037 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 9 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI4 27) chain A residue 38 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q8R0Y6 source Swiss-Prot : SWS_FT_FI5

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