eF-site ID 2c8x-ABI PDB Code 2c8x Chain A, B, I click to enlarge Title thrombin inhibitors Classification HYDROLASE/HYDROLASE INHIBITOR Compound THROMBIN LIGHT CHAIN Source ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; Sequence A:  GEADCGLRPLFEKKSLEDKTERELLESYI B:  IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIV ERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKK WIQKVIDQFGE I:  DFEEIPEEXLQ Description Functional site 1) chain B residue 130 type sequence L description BINDING SITE FOR RESIDUE DMS B 1248 source : AC1 2) chain B residue 162 type sequence I description BINDING SITE FOR RESIDUE DMS B 1248 source : AC1 3) chain B residue 165 type sequence R description BINDING SITE FOR RESIDUE DMS B 1248 source : AC1 4) chain B residue 181 type sequence F description BINDING SITE FOR RESIDUE DMS B 1248 source : AC1 5) chain B residue 127 type sequence E description BINDING SITE FOR RESIDUE DMS B 1249 source : AC2 6) chain B residue 223 type sequence G description BINDING SITE FOR RESIDUE DMS B 1249 source : AC2 7) chain B residue 189 type sequence D description BINDING SITE FOR RESIDUE NA B 1250 source : AC3 8) chain B residue 221 type sequence D description BINDING SITE FOR RESIDUE NA B 1250 source : AC3 9) chain B residue 221 type sequence D description BINDING SITE FOR RESIDUE NA B 1250 source : AC3 10) chain B residue 224 type sequence K description BINDING SITE FOR RESIDUE NA B 1250 source : AC3 11) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 12) chain B residue 60 type sequence L description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 13) chain B residue 60 type sequence L description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 14) chain B residue 96 type sequence W description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 15) chain B residue 97 type sequence R description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 16) chain B residue 98 type sequence N description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 17) chain B residue 99 type sequence L description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 18) chain B residue 189 type sequence D description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 19) chain B residue 190 type sequence A description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 20) chain B residue 191 type sequence C description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 21) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 22) chain B residue 213 type sequence V description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 23) chain B residue 214 type sequence S description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 24) chain B residue 215 type sequence W description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 25) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 26) chain B residue 219 type sequence G description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 27) chain B residue 226 type sequence G description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 28) chain B residue 227 type sequence F description BINDING SITE FOR RESIDUE C5M B 1251 source : AC4 29) chain B residue 34 type sequence F description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 30) chain B residue 36 type sequence K description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 31) chain B residue 38 type sequence Q description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 32) chain B residue 40 type sequence L description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 33) chain B residue 65 type sequence L description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 34) chain B residue 67 type sequence R description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 35) chain B residue 73 type sequence R description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 36) chain B residue 74 type sequence T description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 37) chain B residue 75 type sequence R description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 38) chain B residue 76 type sequence Y description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 39) chain B residue 81 type sequence K description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 40) chain B residue 82 type sequence I description BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2 source : AC5 41) chain I residue 63 type MOD_RES sequence X description Sulfotyrosine => ECO:0000269|PubMed:3513162 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 102 type MOD_RES sequence D description Sulfotyrosine => ECO:0000269|PubMed:3513162 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 195 type MOD_RES sequence S description Sulfotyrosine => ECO:0000269|PubMed:3513162 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 46) chain B residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135

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