eF-site ID 2c5v-A PDB Code 2c5v Chain A click to enlarge Title Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design Classification CELL CYCLE Compound CELL DIVISION PROTEIN KINASE 2 Source Homo sapiens (Human) (2C5V) Sequence A:  MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE TEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA LAHPFFQDVTKPVPHL Description Functional site 1) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 2) chain A residue 31 type sequence A description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 3) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 4) chain A residue 80 type sequence F description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 5) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 6) chain A residue 83 type sequence L description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 7) chain A residue 84 type sequence H description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 8) chain A residue 85 type sequence Q description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 9) chain A residue 86 type sequence D description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 10) chain A residue 89 type sequence K description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 11) chain A residue 134 type sequence L description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 12) chain A residue 145 type sequence D description BINDING SITE FOR RESIDUE CK4 A1297 source : AC1 13) chain A residue 10-33 type prosite sequence IGEGTYGVVYKARNKLTGEVVALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK source prosite : PS00107 14) chain A residue 123-135 type prosite sequence VLHRDLKPQNLLI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI source prosite : PS00108

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