eF-site ID 2c4k-ABCDEF PDB Code 2c4k Chain A, B, C, D, E, F click to enlarge Title Crystal structure of human phosphoribosylpyrophosphate synthetase- associated protein 39 (PAP39) Classification REGULATORY PROTEIN Compound PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE-ASSOCIATED PROTEIN 1 Source null (KPRA_HUMAN) Sequence A:  GYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGE TRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKT ACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAG LTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIP NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHPPITVVG DVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMAT HGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKT VDISLILSEAIRRIHNGESMAYLFR B:  GYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGE TRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKT ACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAG LTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIP NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHPPITVVG DVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMAT HGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKT VDISLILSEAIRRIHNGESMAYLFR C:  GYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGE TRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKT ACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAG LTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIP NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHPPITVVG DVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMAT HGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKT VDISLILSEAIRRIHNGESMAYLFR D:  GYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGE TRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKT ACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAG LTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIP NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHPPITVVG DVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMAT HGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKT VDISLILSEAIRRIHNGESMAYLFR E:  GYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGE TRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKT ACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAG LTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIP NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHPPITVVG DVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMAT HGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKT VDISLILSEAIRRIHNGESMAYLFR F:  GYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGE TRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKT ACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAG LTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIP NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHPPITVVG DVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMAT HGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKT VDISLILSEAIRRIHNGESMAYLFR Description Functional site 1) chain A residue 344 type sequence S description BINDING SITE FOR RESIDUE SO4 B1351 source : AC1 2) chain A residue 345 type sequence M description BINDING SITE FOR RESIDUE SO4 B1351 source : AC1 3) chain B residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 B1351 source : AC1 4) chain B residue 56 type sequence R description BINDING SITE FOR RESIDUE SO4 B1351 source : AC1 5) chain E residue 110 type sequence R description BINDING SITE FOR RESIDUE SO4 B1351 source : AC1 6) chain B residue 110 type sequence R description BINDING SITE FOR RESIDUE SO4 B1352 source : AC2 7) chain B residue 344 type sequence S description BINDING SITE FOR RESIDUE SO4 B1352 source : AC2 8) chain B residue 345 type sequence M description BINDING SITE FOR RESIDUE SO4 B1352 source : AC2 9) chain E residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 B1352 source : AC2 10) chain E residue 56 type sequence R description BINDING SITE FOR RESIDUE SO4 B1352 source : AC2 11) chain C residue 110 type sequence R description BINDING SITE FOR RESIDUE SO4 C1351 source : AC3 12) chain C residue 343 type sequence E description BINDING SITE FOR RESIDUE SO4 C1351 source : AC3 13) chain C residue 344 type sequence S description BINDING SITE FOR RESIDUE SO4 C1351 source : AC3 14) chain C residue 345 type sequence M description BINDING SITE FOR RESIDUE SO4 C1351 source : AC3 15) chain F residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 C1351 source : AC3 16) chain F residue 55 type sequence V description BINDING SITE FOR RESIDUE SO4 C1351 source : AC3 17) chain F residue 56 type sequence R description BINDING SITE FOR RESIDUE SO4 C1351 source : AC3 18) chain C residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 D1351 source : AC4 19) chain C residue 56 type sequence R description BINDING SITE FOR RESIDUE SO4 D1351 source : AC4 20) chain D residue 344 type sequence S description BINDING SITE FOR RESIDUE SO4 D1351 source : AC4 21) chain D residue 345 type sequence M description BINDING SITE FOR RESIDUE SO4 D1351 source : AC4 22) chain F residue 110 type sequence R description BINDING SITE FOR RESIDUE SO4 D1351 source : AC4 23) chain A residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 E1351 source : AC5 24) chain A residue 56 type sequence R description BINDING SITE FOR RESIDUE SO4 E1351 source : AC5 25) chain A residue 110 type sequence R description BINDING SITE FOR RESIDUE SO4 E1351 source : AC5 26) chain E residue 344 type sequence S description BINDING SITE FOR RESIDUE SO4 E1351 source : AC5 27) chain E residue 345 type sequence M description BINDING SITE FOR RESIDUE SO4 E1351 source : AC5 28) chain E residue 90 type sequence R description BINDING SITE FOR RESIDUE SO4 E1352 source : AC6 29) chain D residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 F1351 source : AC7 30) chain D residue 56 type sequence R description BINDING SITE FOR RESIDUE SO4 F1351 source : AC7 31) chain D residue 110 type sequence R description BINDING SITE FOR RESIDUE SO4 F1351 source : AC7 32) chain F residue 344 type sequence S description BINDING SITE FOR RESIDUE SO4 F1351 source : AC7 33) chain F residue 345 type sequence M description BINDING SITE FOR RESIDUE SO4 F1351 source : AC7 34) chain B residue 25 type sequence R description BINDING SITE FOR RESIDUE TAM B1353 source : AC8 35) chain B residue 160 type sequence Y description BINDING SITE FOR RESIDUE TAM B1353 source : AC8 36) chain B residue 324 type sequence K description BINDING SITE FOR RESIDUE TAM B1353 source : AC8 37) chain B residue 325 type sequence T description BINDING SITE FOR RESIDUE TAM B1353 source : AC8 38) chain B residue 327 type sequence D description BINDING SITE FOR RESIDUE TAM B1353 source : AC8 39) chain A residue 177 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 177 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 41) chain C residue 177 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 42) chain D residue 177 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 43) chain E residue 177 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2 44) chain F residue 177 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2

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