eF-site ID 2c4g-C
PDB Code 2c4g
Chain C

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Title STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514
Classification TRANSFERASE
Compound CELL DIVISION PROTEIN KINASE 2
Source (CCNA2_HUMAN)
Sequence C:  VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD
TETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYL
VFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC
HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT
YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT
RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP
SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK
AALAHPFFQDVTKPVPHLRL
Description (1)  CELL DIVISION PROTEIN KINASE 2 (E.C.2.7.1.37), CYCLIN A2


Functional site

1) chain C
residue 10
type
ligand
sequence I
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

2) chain C
residue 31
type
ligand
sequence A
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

3) chain C
residue 33
type
ligand
sequence K
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

4) chain C
residue 80
type
ligand
sequence F
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

5) chain C
residue 81
type
ligand
sequence E
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

6) chain C
residue 82
type
ligand
sequence F
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

7) chain C
residue 83
type
ligand
sequence L
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

8) chain C
residue 84
type
ligand
sequence H
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

9) chain C
residue 85
type
ligand
sequence Q
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

10) chain C
residue 86
type
ligand
sequence D
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

11) chain C
residue 134
type
ligand
sequence L
description BINDING SITE FOR RESIDUE 514 C 306
source : AC4

12) chain C
residue 10
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence I
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

13) chain C
residue 18
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence V
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

14) chain C
residue 31
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence A
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

15) chain C
residue 33
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence K
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

16) chain C
residue 51
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence E
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

17) chain C
residue 64
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence V
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

18) chain C
residue 80-86
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence FEFLHQD
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

19) chain C
residue 89
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence K
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

20) chain C
residue 134
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence L
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

21) chain C
residue 145
type binding
ligand 514: (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM
sequence D
description (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM binding site
source pdb_hetatom : 514_2c4g_C_306

22) chain C
residue 131
type catalytic
ligand
sequence Q
description Annotated By Reference To The Literature 1ir3
source CSA : CSA2

23) chain C
residue 127
type catalytic
ligand
sequence D
description Annotated By Reference To The Literature 1ir3
source CSA : CSA2

24) chain C
residue 127
type catalytic
ligand
sequence D
description Annotated By Reference To The Literature 1ir3
source CSA : CSA4

25) chain C
residue 129
type catalytic
ligand
sequence K
description Annotated By Reference To The Literature 1ir3
source CSA : CSA4

26) chain C
residue 127
type catalytic
ligand
sequence D
description Annotated By Reference To The Literature 1ir3
source CSA : CSA6

27) chain C
residue 129
type catalytic
ligand
sequence K
description Annotated By Reference To The Literature 1ir3
source CSA : CSA6

28) chain C
residue 165
type catalytic
ligand
sequence T
description Annotated By Reference To The Literature 1ir3
source CSA : CSA6

29) chain C
residue 127
type catalytic
ligand
sequence D
description Annotated By Reference To The Literature 1ir3
source CSA : CSA8

30) chain C
residue 129
type catalytic
ligand
sequence K
description Annotated By Reference To The Literature 1ir3
source CSA : CSA8

31) chain C
residue 132
type catalytic
ligand
sequence N
description Annotated By Reference To The Literature 1ir3
source CSA : CSA8


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