eF-site ID 2c4g-A PDB Code 2c4g Chain A click to enlarge Title STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514 Classification TRANSFERASE Compound CELL DIVISION PROTEIN KINASE 2 Source (CCNA2_HUMAN) Sequence A:  PLVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR LDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS AKAALAHPFFQDVTKPVPHLR Description Functional site 1) chain A residue 256 type sequence D description BINDING SITE FOR RESIDUE SO4 A 305 source : AC1 2) chain A residue 257 type sequence E description BINDING SITE FOR RESIDUE SO4 A 305 source : AC1 3) chain A residue 260 type sequence R description BINDING SITE FOR RESIDUE SO4 A 305 source : AC1 4) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 5) chain A residue 31 type sequence A description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 6) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 7) chain A residue 80 type sequence F description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 8) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 9) chain A residue 82 type sequence F description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 10) chain A residue 83 type sequence L description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 11) chain A residue 84 type sequence H description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 12) chain A residue 85 type sequence Q description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 13) chain A residue 86 type sequence D description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 14) chain A residue 89 type sequence K description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 15) chain A residue 134 type sequence L description BINDING SITE FOR RESIDUE 514 A 306 source : AC3 16) chain A residue 10-33 type prosite sequence IGEGTYGVVYKARNKLTGEVVALK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK source prosite : PS00107 17) chain A residue 123-135 type prosite sequence VLHRDLKPQNLLI description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI source prosite : PS00108

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