eF-site ID 2c46-ABCD PDB Code 2c46 Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase Classification TRANSFERASE Compound MRNA CAPPING ENZYME Source Homo sapiens (Human) (MCE1_HUMAN) Sequence A:  NLYFQSMAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPR YDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFY DRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFP ELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQA RPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDED B:  ENLYFQSNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYD SQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDR NDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNER NELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQ ARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDE D C:  ENLYFQSNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYD SQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDR NDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFELI GVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPP GIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDED D:  NKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEEN RFHPSMLSNYLKSVKMGLLVDLTNTSRFYDRNDIEKEGIK YIKLQCKGHGECPTTENTETFIRLCERFELIGVHCTHGFN RTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLK ELFRRYGDIEEAPPPPLLPDWCFEDDEDE Description Functional site 1) chain A residue 126 type ACT_SITE sequence C description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 126 type ACT_SITE sequence C description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 126 type ACT_SITE sequence C description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160 source Swiss-Prot : SWS_FT_FI1 4) chain D residue 126 type ACT_SITE sequence C description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 124-134 type prosite sequence VHCTHGFNRTG description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCthGfnRTG source prosite : PS00383

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