eF-site ID 2bzl-A PDB Code 2bzl Chain A click to enlarge Title CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1. 65 A RESOLUTION Classification HYDROLASE Compound TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 14 Source (PTN14_HUMAN) Sequence A:  ERFRTLKKKLMVFTEYEQIPKKKANGIFSTAALPENAERS RIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEW HYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRT KSHRYWPKKHSSATYGKFKVTTKFRTDSVCYATTGLKVKH LLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVR RHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYC LEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQF LQNS Description Functional site 1) chain A residue 1021 type sequence R description BINDING SITE FOR RESIDUE SO4 A2185 source : AC1 2) chain A residue 1025 type sequence K description BINDING SITE FOR RESIDUE SO4 A2185 source : AC1 3) chain A residue 1045 type sequence R description BINDING SITE FOR RESIDUE SO4 A2185 source : AC1 4) chain A residue 1030 type sequence H description BINDING SITE FOR RESIDUE SO4 A2186 source : AC2 5) chain A residue 1031 type sequence S description BINDING SITE FOR RESIDUE SO4 A2186 source : AC2 6) chain A residue 1032 type sequence S description BINDING SITE FOR RESIDUE SO4 A2186 source : AC2 7) chain A residue 1121 type sequence C description BINDING SITE FOR RESIDUE EDO A2187 source : AC3 8) chain A residue 1122 type sequence S description BINDING SITE FOR RESIDUE EDO A2187 source : AC3 9) chain A residue 1126 type sequence G description BINDING SITE FOR RESIDUE EDO A2187 source : AC3 10) chain A residue 1127 type sequence R description BINDING SITE FOR RESIDUE EDO A2187 source : AC3 11) chain A residue 1169 type sequence Q description BINDING SITE FOR RESIDUE EDO A2187 source : AC3 12) chain A residue 917 type sequence P description BINDING SITE FOR RESIDUE EDO A2188 source : AC4 13) chain A residue 918 type sequence K description BINDING SITE FOR RESIDUE EDO A2188 source : AC4 14) chain A residue 919 type sequence K description BINDING SITE FOR RESIDUE EDO A2188 source : AC4 15) chain A residue 1119-1129 type prosite sequence VHCSAGVGRTG description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG source prosite : PS00383 16) chain A residue 1079 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 1121 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 1165 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 1121 type ACT_SITE sequence C description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044 source Swiss-Prot : SWS_FT_FI1

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