eF-site ID 2bzg-A PDB Code 2bzg Chain A click to enlarge Title Crystal structure of thiopurine S-methyltransferase. Classification TRANSFERASE Compound THIOPURINE S-METHYLTRANSFERASE Source (TPMT_HUMAN) Sequence A:  EVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTF LKGKSGLRVFFPLCGKAVEXKWFADRGHSVVGVEISELGI QEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIF DLPRTNIGKFDXIWDRGALVAINPGDRKCYADTXFSLLGK KFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRC LEKVDAFEERHKSWGIDCLFEKLYLLTEK Description (1)  THIOPURINE S-METHYLTRANSFERASE (E.C.2.1.1.67) Functional site 1) chain A residue 26 type sequence L description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 2) chain A residue 29 type sequence W description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 3) chain A residue 33 type sequence W description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 4) chain A residue 40 type sequence F description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 5) chain A residue 69 type sequence L description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 6) chain A residue 70 type sequence C description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 7) chain A residue 90 type sequence E description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 8) chain A residue 91 type sequence I description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 9) chain A residue 133 type sequence C description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 10) chain A residue 134 type sequence S description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 11) chain A residue 135 type sequence I description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 12) chain A residue 152 type sequence R description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 13) chain A residue 153 type sequence G description BINDING SITE FOR RESIDUE SAH A1246 source : AC1 14) chain A residue 64 type sequence R description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 15) chain A residue 111 type sequence P description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 16) chain A residue 112 type sequence I description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 17) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 18) chain A residue 114 type sequence E description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 19) chain A residue 131 type sequence Y description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 20) chain A residue 141 type sequence T description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 21) chain A residue 142 type sequence N description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 22) chain A residue 143 type sequence I description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 23) chain A residue 229 type sequence S description BINDING SITE FOR RESIDUE B3P A1247 source : AC2 24) chain A residue 40 type BINDING sequence F description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 29 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI1 26) chain A residue 69 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI1 27) chain A residue 90 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 28) chain A residue 134 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 29) chain A residue 152 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI1 30) chain A residue 58 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4

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