eF-site ID 2bmc-C PDB Code 2bmc Chain C click to enlarge Title Aurora-2 T287D T288D complexed with PHA-680632 Classification TRANSFERASE Compound SERINE THREONINE-PROTEIN KINASE 6 Source (STK6_HUMAN) Sequence C:  KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVL FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAT RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANAL SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVTLDYL PPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQE TYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLRE VLEHPWITANSSKPSNC Description (1)  SERINE THREONINE-PROTEIN KINASE 6 (E.C.2.7.1.37) Functional site 1) chain C residue 140 type sequence G description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 2) chain C residue 141 type sequence K description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 3) chain C residue 142 type sequence G description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 4) chain C residue 147 type sequence V description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 5) chain C residue 160 type sequence A description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 6) chain C residue 162 type sequence K description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 7) chain C residue 194 type sequence L description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 8) chain C residue 211 type sequence E description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 9) chain C residue 212 type sequence Y description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 10) chain C residue 213 type sequence A description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 11) chain C residue 214 type sequence P description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 12) chain C residue 216 type sequence G description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 13) chain C residue 260 type sequence E description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 14) chain C residue 261 type sequence N description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 15) chain C residue 263 type sequence L description BINDING SITE FOR RESIDUE MPY C1394 source : AC3 16) chain C residue 215 type sequence L description BINDING SITE FOR RESIDUE MPY D1395 source : AC4 17) chain C residue 258 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 18) chain C residue 256 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:14580337 source Swiss-Prot : SWS_FT_FI1 19) chain C residue 143 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 20) chain C residue 162 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 21) chain C residue 211 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 22) chain C residue 260 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 23) chain C residue 274 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 24) chain C residue 342 type MOD_RES sequence S description Phosphoserine; by PKA and PAK => ECO:0000269|PubMed:16246726 source Swiss-Prot : SWS_FT_FI5

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