|
|
eF-site ID
|
2bks-A |
|
PDB Code
|
2bks |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
crystal structure of Renin-PF00074777 complex |
|
Classification
|
HYDROLASE |
|
Compound
|
Renin |
|
Source
|
Homo sapiens (Human) (RENI_HUMAN) |
|
|
Sequence
|
A: |
SSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVP
SSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGT
VSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGV
VGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSE
NLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSV
GSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKK
RLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESY
SSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRR
NNRIGFALAR
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
33 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000269|PubMed:20927107
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
219 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000269|PubMed:20927107
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
70 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
30-41 |
| type |
prosite |
| sequence |
VVFDTGSSNVWV
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
|
| source |
prosite : PS00141
|
|
|
5)
|
chain |
A |
| residue |
216-227 |
| type |
prosite |
| sequence |
ALVDTGASYISG
|
| description |
ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
|
| source |
prosite : PS00141
|
|
|
|