eF-site ID 2bfd-B PDB Code 2bfd Chain B click to enlarge Title Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch Classification OXIDOREDUCTASE Compound 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT Source (ODBB_HUMAN) Sequence B:  AHFEYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDVAF GGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTG ATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLFNCGSL TIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQ AKGLLLSCIEDKNPCIFFEPKILYRAAAEEVPIEPYNIPL SQAEVIQEGSDVTLVAWGTQVHVIREVASMAKEKLGVSCE VIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGGFASE ISSTVQEECFLNLEAPISRVCGYDTPFPHIFEPFYIPDKW KCYDALRKMINY Description Functional site 1) chain B residue 128 type sequence G description BINDING SITE FOR RESIDUE K B 502 source : AC4 2) chain B residue 130 type sequence L description BINDING SITE FOR RESIDUE K B 502 source : AC4 3) chain B residue 131 type sequence T description BINDING SITE FOR RESIDUE K B 502 source : AC4 4) chain B residue 178 type sequence C description BINDING SITE FOR RESIDUE K B 502 source : AC4 5) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE K B 502 source : AC4 6) chain B residue 183 type sequence N description BINDING SITE FOR RESIDUE K B 502 source : AC4 7) chain B residue 46 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 8) chain B residue 74 type sequence L description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 9) chain B residue 76 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 10) chain B residue 98 type sequence Q description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 11) chain B residue 102 type sequence Y description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 12) chain B residue 260 type sequence W description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 13) chain B residue 284 type sequence T description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 14) chain B residue 290 type sequence E description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 15) chain B residue 294 type sequence T description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 16) chain B residue 309 type sequence R description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 17) chain B residue 58 type sequence V description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 18) chain B residue 182 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q6P3A8 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 102 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 20) chain B residue 128 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 21) chain B residue 130 type BINDING sequence L description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 22) chain B residue 131 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 23) chain B residue 178 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 24) chain B residue 181 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 25) chain B residue 183 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 26) chain B residue 191 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3

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