eF-site ID 2bfd-AB PDB Code 2bfd Chain A, B click to enlarge Title Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch Classification OXIDOREDUCTASE Compound 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT Source (ODBB_HUMAN) Sequence A:  KPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIIN PSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISF YMTNYGEEGTHVGSAAALDNTDLVFGQAREAGVLMYRDYP LELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLA TQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGF NFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPG YGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMT YRIGSTDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVM EAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHL QTYGEHYPLDHFDK B:  AHFEYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDVAF GGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTG ATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLFNCGSL TIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQ AKGLLLSCIEDKNPCIFFEPKILYRAAAEEVPIEPYNIPL SQAEVIQEGSDVTLVAWGTQVHVIREVASMAKEKLGVSCE VIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGGFASE ISSTVQEECFLNLEAPISRVCGYDTPFPHIFEPFYIPDKW KCYDALRKMINY Description Functional site 1) chain A residue 112 type sequence Q description BINDING SITE FOR RESIDUE K A 501 source : AC1 2) chain A residue 161 type sequence S description BINDING SITE FOR RESIDUE K A 501 source : AC1 3) chain A residue 163 type sequence P description BINDING SITE FOR RESIDUE K A 501 source : AC1 4) chain A residue 166 type sequence T description BINDING SITE FOR RESIDUE K A 501 source : AC1 5) chain A residue 167 type sequence Q description BINDING SITE FOR RESIDUE K A 501 source : AC1 6) chain A residue 193 type sequence E description BINDING SITE FOR RESIDUE MN A 503 source : AC2 7) chain A residue 222 type sequence N description BINDING SITE FOR RESIDUE MN A 503 source : AC2 8) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE MN A 503 source : AC2 9) chain A residue 53 type sequence P description BINDING SITE FOR RESIDUE CL A 504 source : AC3 10) chain A residue 55 type sequence E description BINDING SITE FOR RESIDUE CL A 504 source : AC3 11) chain A residue 369 type sequence Q description BINDING SITE FOR RESIDUE CL A 504 source : AC3 12) chain B residue 128 type sequence G description BINDING SITE FOR RESIDUE K B 502 source : AC4 13) chain B residue 130 type sequence L description BINDING SITE FOR RESIDUE K B 502 source : AC4 14) chain B residue 131 type sequence T description BINDING SITE FOR RESIDUE K B 502 source : AC4 15) chain B residue 178 type sequence C description BINDING SITE FOR RESIDUE K B 502 source : AC4 16) chain B residue 181 type sequence D description BINDING SITE FOR RESIDUE K B 502 source : AC4 17) chain B residue 183 type sequence N description BINDING SITE FOR RESIDUE K B 502 source : AC4 18) chain A residue 112 type sequence Q description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 19) chain A residue 114 type sequence R description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 20) chain A residue 162 type sequence S description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 21) chain A residue 164 type sequence L description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 22) chain A residue 192 type sequence G description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 23) chain A residue 193 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 24) chain A residue 194 type sequence G description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 25) chain A residue 195 type sequence A description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 26) chain A residue 198 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 27) chain A residue 220 type sequence R description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 28) chain A residue 222 type sequence N description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 29) chain A residue 224 type sequence Y description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 30) chain A residue 225 type sequence A description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 31) chain A residue 226 type sequence I description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 32) chain B residue 46 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 33) chain B residue 74 type sequence L description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 34) chain B residue 76 type sequence E description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 35) chain B residue 98 type sequence Q description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 36) chain B residue 102 type sequence Y description BINDING SITE FOR RESIDUE TPP A 601 source : AC5 37) chain A residue 374 type sequence Q description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 38) chain B residue 260 type sequence W description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 39) chain B residue 284 type sequence T description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 40) chain B residue 290 type sequence E description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 41) chain B residue 294 type sequence T description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 42) chain B residue 309 type sequence R description BINDING SITE FOR RESIDUE GOL B 701 source : AC6 43) chain A residue 73 type sequence I description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 44) chain A residue 76 type sequence E description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 45) chain A residue 82 type sequence R description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 46) chain A residue 349 type sequence F description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 47) chain B residue 58 type sequence V description BINDING SITE FOR RESIDUE MPD B 901 source : AC7 48) chain A residue 335 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P50136 source Swiss-Prot : SWS_FT_FI6 49) chain A residue 76 type catalytic sequence E description 280 source MCSA : MCSA1 50) chain A residue 162 type catalytic sequence S description 280 source MCSA : MCSA1 51) chain A residue 292 type catalytic sequence S description 280 source MCSA : MCSA1 52) chain B residue 131 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 53) chain B residue 178 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 54) chain B residue 181 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 55) chain B residue 183 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 56) chain A residue 193 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 57) chain A residue 194 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 58) chain A residue 195 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 59) chain A residue 220 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 60) chain A residue 222 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 61) chain A residue 224 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 62) chain B residue 102 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 63) chain B residue 128 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 64) chain B residue 130 type BINDING sequence L description BINDING => ECO:0000269|PubMed:10745006, ECO:0007744|PDB:1DTW source Swiss-Prot : SWS_FT_FI1 65) chain B residue 182 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:Q6P3A8 source Swiss-Prot : SWS_FT_FI2 66) chain B residue 191 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3

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